Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans
This study provides first-in-human evidence of the potential of mTUS as a precise, safe and effective non-invasive neuromodulation technique for neuropsychiatric disorders involving deep brain regions, offering a safer and more accessible alternative to invasive approaches.
Authors
- Clément Debacker (ORCID: https://orcid.org/0000-0003-4887-7920)
- Catherine Oppenheim (ORCID: https://orcid.org/0000-0003-3410-0862)
- P. Annic
- Khaoussou Sylla
- Alexandre Houdouin
- Ciro Paolillo (ORCID: https://orcid.org/0000-0002-8027-5551)
- Alice Le Berre
- Mylène Moyal (ORCID: https://orcid.org/0000-0002-0523-9374)
- Arnaud Cachia (ORCID: https://orcid.org/0000-0003-2125-4985)
- Ghita Dadi (ORCID: https://orcid.org/0009-0002-5792-3714)
- Jean‐François Aubry (ORCID: https://orcid.org/0000-0003-2644-3945)
- Thomas J. Manuel (ORCID: https://orcid.org/0000-0003-3053-935X)
- Alexandre Haroche (ORCID: https://orcid.org/0000-0002-2164-4847)
- Tarek Sharshar (ORCID: https://orcid.org/0000-0003-2276-0951)
- Thomas Tiennot (ORCID: https://orcid.org/0000-0002-5486-3165)
- Thierry Gallarda
- David Attali (ORCID: https://orcid.org/0000-0002-8295-3889)
- Marion Plaze (ORCID: https://orcid.org/0000-0001-9022-4945)
- Rossella Letizia Mancusi (ORCID: https://orcid.org/0000-0002-6448-6279)
- Alexandre Dizeux (ORCID: https://orcid.org/0000-0002-7394-143X)
- Sylvain Charron (ORCID: https://orcid.org/0000-0001-9511-9693)
- Adèle Henensal
- Maliesse Lui
- Maxime Daniel
- Mickaël Tanter (ORCID: https://orcid.org/0000-0001-7739-8051)
- Sabrina Lekcir
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Centre Hospitalier Sainte-Anne (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- FHU Neurovasc (FR)
- ESPCI Paris (FR)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.brs.2025.04.018
- Citations
- 21
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 14.16