Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans

This study provides first-in-human evidence of the potential of mTUS as a precise, safe and effective non-invasive neuromodulation technique for neuropsychiatric disorders involving deep brain regions, offering a safer and more accessible alternative to invasive approaches.

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Publication Details

Journal
Brain stimulation
Published
2025-04-29
DOI
https://doi.org/10.1016/j.brs.2025.04.018
Citations
21
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
14.16
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article

Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans

Clément Debacker, Catherine Oppenheim, P. Annic, Khaoussou Sylla et al.
21 citations
Brain stimulation
Ultrasound and Hyperthermia Applications
14.16
article

Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans

Clément Debacker, Catherine Oppenheim, P. Annic, Khaoussou Sylla, Alexandre Houdouin, Ciro Paolillo, Alice Le Berre, Mylène Moyal, Arnaud Cachia, Ghita Dadi, Jean‐François Aubry, Thomas J. Manuel, Alexandre Haroche, Tarek Sharshar, Thomas Tiennot, Thierry Gallarda, David Attali, Marion Plaze, Rossella Letizia Mancusi, Alexandre Dizeux, Sylvain Charron, Adèle Henensal, Maliesse Lui, Maxime Daniel, Mickaël Tanter, Sabrina Lekcir
article en
21 citations

Abstract

This study provides first-in-human evidence of the potential of mTUS as a precise, safe and effective non-invasive neuromodulation technique for neuropsychiatric disorders involving deep brain regions, offering a safer and more accessible alternative to invasive approaches.

Brain stimulationVol. 18(3)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris Cité (FR), Université Paris Sciences et Lettres (FR), Centre Hospitalier Sainte-Anne (FR), Institut de Psychiatrie et Neurosciences de Paris (FR), FHU Neurovasc (FR), ESPCI Paris (FR)
Good health and well-being
Openalex Percentile: Top 1%
Ultrasound and Hyperthermia Applications
14.16
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