Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial

Oral step-down therapy on day 5 was not associated with worse clinical cure for Enterobacterales BSI.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2025-04-29
DOI
https://doi.org/10.1016/j.ijid.2025.107917
Citations
3
Primary Topic
Antibiotic Use and Resistance
Type
article
Field-Weighted Citation Impact
3.79

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article

Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial

Andrés Martín-Aspas, Esperanza Merino, Emanuele Rando, José María Bravo-Ferrer et al.
3 citations
International Journal of Infectious Diseases
Antibiotic Use and Resistance
3.79
article

Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial

Andrés Martín-Aspas, Esperanza Merino, Emanuele Rando, José María Bravo-Ferrer, Mercedes Delgado-Valverde, Miguel Ángel Goenaga-Sánchez, Manuel Recio, Patricia Jiménez Aguilar, Fátima Galán‐Sánchez, Luis Eduardo López-Cortés, Clara Rosso-Fernández, Juan José Castón, José Ramón Yuste, Josune Goikoetxea Aguirre, Pilar Retamar, Mariona Xercavins-Valls, Carlos Armiñanzas, Jesús Rodríguez‐Baño, Patricia Capón González, Carlos Ruiz de Alegría Puig, Diego Vicente Anza, Francisco Arnaíz de las Revillas, Lucía Martínez Lamas, Laura Guío Carrión, Germán Bou, María del Carmen Martínez-Rubio, Carmen Sáez-Béjar, Juan Carlos Rodrı́guez, José Leiva, María José Blanco Vidal, José Andrés, Carmen de las Cuevas, Lucía Boix-Palop, Belén Loeches, María de la Mar Bustamante Rodríguez
article en
3 citations

Abstract

Oral step-down therapy on day 5 was not associated with worse clinical cure for Enterobacterales BSI.

International Journal of Infectious DiseasesVol. 156
Hospital Universitario La Paz (ES), Universidad de Cádiz (ES), Hospital Universitario Virgen Macarena (ES), University Hospital Mútua de Terrassa (ES), Biomedical Research and Innovation Institute of Cadiz (ES), Mútua Terrassa (ES), Hospital Universitario de La Princesa (ES), Clinica Universidad de Navarra (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Hospital Universitario Puerto Real (ES), Donostiako Unibertsitate Ospitalea (ES), Hospital Universitario Puerta del Mar (ES), Hospital Universitario Lucus Augusti (ES), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
Spanish Clinical Research Network, Instituto de Salud Carlos III
Good health and well-being
Openalex Percentile: Top 7%
Antibiotic Use and Resistance
3.79
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