Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial
Oral step-down therapy on day 5 was not associated with worse clinical cure for Enterobacterales BSI.
Authors
- Andrés Martín-Aspas (ORCID: https://orcid.org/0000-0002-3086-9095)
- Esperanza Merino (ORCID: https://orcid.org/0000-0003-3854-4874)
- Emanuele Rando (ORCID: https://orcid.org/0000-0001-6573-9584)
- José María Bravo-Ferrer (ORCID: https://orcid.org/0000-0002-4638-5001)
- Mercedes Delgado-Valverde
- Miguel Ángel Goenaga-Sánchez
- Manuel Recio (ORCID: https://orcid.org/0000-0001-8992-3677)
- Patricia Jiménez Aguilar
- Fátima Galán‐Sánchez (ORCID: https://orcid.org/0000-0003-0101-6701)
- Luis Eduardo López-Cortés (ORCID: https://orcid.org/0000-0002-9347-527X)
- Clara Rosso-Fernández (ORCID: https://orcid.org/0000-0002-5463-2826)
- Juan José Castón (ORCID: https://orcid.org/0000-0002-7477-2033)
- José Ramón Yuste (ORCID: https://orcid.org/0000-0001-8502-9539)
- Josune Goikoetxea Aguirre
- Pilar Retamar (ORCID: https://orcid.org/0000-0003-2147-809X)
- Mariona Xercavins-Valls
- Carlos Armiñanzas (ORCID: https://orcid.org/0000-0001-9009-7552)
- Jesús Rodríguez‐Baño (ORCID: https://orcid.org/0000-0001-6732-9001)
- Patricia Capón González
- Carlos Ruiz de Alegría Puig (ORCID: https://orcid.org/0000-0002-2892-8359)
- Diego Vicente Anza
- Francisco Arnaíz de las Revillas (ORCID: https://orcid.org/0000-0002-0611-6309)
- Lucía Martínez Lamas
- Laura Guío Carrión
- Germán Bou (ORCID: https://orcid.org/0000-0001-8837-0062)
- María del Carmen Martínez-Rubio
- Carmen Sáez-Béjar
- Juan Carlos Rodrı́guez (ORCID: https://orcid.org/0000-0001-8007-5739)
- José Leiva (ORCID: https://orcid.org/0000-0002-8380-3161)
- María José Blanco Vidal
- José Andrés
- Carmen de las Cuevas
- Lucía Boix-Palop (ORCID: https://orcid.org/0000-0002-4080-0008)
- Belén Loeches
- María de la Mar Bustamante Rodríguez (ORCID: https://orcid.org/0000-0002-3546-2163)
Institutions
- Hospital Universitario La Paz (ES)
- Universidad de Cádiz (ES)
- Hospital Universitario Virgen Macarena (ES)
- University Hospital Mútua de Terrassa (ES)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Mútua Terrassa (ES)
- Hospital Universitario de La Princesa (ES)
- Clinica Universidad de Navarra (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitario Puerto Real (ES)
- Donostiako Unibertsitate Ospitalea (ES)
- Hospital Universitario Puerta del Mar (ES)
- Hospital Universitario Lucus Augusti (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.ijid.2025.107917
- Citations
- 3
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 3.79
Funders
- Spanish Clinical Research Network
- Instituto de Salud Carlos III