Inhibition of adenosine/A2A receptor signaling suppresses dermal fibrosis by enhancing fatty acid oxidation
Our study highlights the crucial interplay between adenosine metabolism-A2A receptor axis and FAO in SSc-associated skin fibrosis, suggesting that targeting the adenosine receptor A2A-FAO metabolic axis offers a promising therapeutic strategy for skin fibrosis.
Authors
- Xiaoye Zhang (ORCID: https://orcid.org/0000-0002-3580-8259)
- Yuzi Tian (ORCID: https://orcid.org/0000-0001-5267-2456)
- Hong Liu (ORCID: https://orcid.org/0000-0002-0863-7853)
- Xiang Chen (ORCID: https://orcid.org/0000-0001-8187-636X)
- Jia Guo (ORCID: https://orcid.org/0000-0001-8454-8951)
- Xiaoyun Xie (ORCID: https://orcid.org/0009-0002-1598-5802)
- Junyu Zhou (ORCID: https://orcid.org/0000-0002-0389-5618)
- Hui Luo (ORCID: https://orcid.org/0000-0003-2527-0237)
- Jinjian Sun
- Xiaoru Hu
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12964-025-02210-2
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation