Unravelling the Genotype of the Apical Variant of Hypertrophic Cardiomyopathy in a Swedish Cohort
In ApHCM, a positive genotype was found less frequently compared to classic HCM. Only 14% of patients with ApHCM were found to be genotype positive, indicating that apical hypertrophy represents a genetically unique population with low risk of mortality. Nevertheless, patients with ApHCM faced higher rates of atrial fibrillation, ventricular arrhythmias, and apical aneurysms.
Authors
- Antheia Kissopoulou (ORCID: https://orcid.org/0000-0002-8988-5591)
- Rada Ellegård (ORCID: https://orcid.org/0000-0002-2097-6778)
- Cecilia Gunnarsson (ORCID: https://orcid.org/0000-0001-9474-6820)
- Henrik Gréen (ORCID: https://orcid.org/0000-0002-8015-5728)
- Jan‐Erik Karlsson (ORCID: https://orcid.org/0000-0003-2632-4065)
- Eva Fernlund (ORCID: https://orcid.org/0000-0001-6508-9411)
Institutions
- Linköping University (SE)
- Lund University (SE)
- Swedish National Board of Forensic Medicine (SE)
- Region Jönköpings län (SE)
- Skåne University Hospital (SE)
- Linköping University Hospital (SE)
Publication Details
- Journal
- Genes
- Published
- 2025-04-26
- DOI
- https://doi.org/10.3390/genes16050494
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Linköpings Universitet
- Futurum - Akademin för Hälsa och Vård, Region Jönköpings läns