Patterns of phosphorylated tau accumulation in a spectrum of acquired and developmental brain lesions associated with refractory epilepsy
Our findings highlight localized and distinct patterns of pTau in some epilepsy pathologies. Plausible pathomechanisms include local vascular insufficiency, neuronal dysmaturation, and aging as well as seizure activity and provide direction for future exploration.
Authors
- Fenglai Xiao (ORCID: https://orcid.org/0000-0003-1308-6539)
- Joanna Bartkiewicz (ORCID: https://orcid.org/0000-0002-5020-6109)
- Joan Liu (ORCID: https://orcid.org/0000-0002-0777-5189)
- Anna Miserocchi
- Ingmar Blümcke (ORCID: https://orcid.org/0000-0001-8676-0788)
- Jane de Tisi (ORCID: https://orcid.org/0000-0002-7666-2268)
- Roland Coras (ORCID: https://orcid.org/0000-0002-8352-2773)
- Maria Thom (ORCID: https://orcid.org/0000-0001-7712-2629)
- Matthias J. Koepp (ORCID: https://orcid.org/0000-0002-4277-8000)
- Hanaa El Hachami
- Alicja Mrzyglod
- Andrew W. McEvoy (ORCID: https://orcid.org/0000-0002-1078-3761)
- Maritchka Ryniejska
- Anya Mebrouk
Institutions
- Universitätsklinikum Erlangen (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Westminster (GB)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1111/epi.18418
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- University College London Hospitals NHS Foundation Trust
- Epilepsy Society
- UCLH Biomedical Research Centre