Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy
Fes activity modulates the inflammatory cytokine presentation and T-cell priming capabilities of macrophages, supporting the potential of Fes as a target for developing therapeutic and biomarker strategies to improve cancer immunotherapy.
Authors
- Amber L. Simpson (ORCID: https://orcid.org/0000-0002-4387-8417)
- Madhuri Koti (ORCID: https://orcid.org/0000-0003-1490-2577)
- Kathrin Tyryshkin (ORCID: https://orcid.org/0000-0002-7726-6654)
- Connie S. Zhang
- Caitlyn Vlasschaert (ORCID: https://orcid.org/0009-0003-8466-7602)
- Natasha Dmytryk
- Jeffrey Mewburn (ORCID: https://orcid.org/0000-0002-1365-4228)
- David P. LeBrun (ORCID: https://orcid.org/0000-0002-8695-0247)
- Faizah Alotaibi (ORCID: https://orcid.org/0000-0002-3282-1845)
- Peter A. Greer (ORCID: https://orcid.org/0000-0002-7809-5105)
- Yan Gao
- Andrew Garven
- Danielle Harper (ORCID: https://orcid.org/0009-0009-1184-4923)
- Brian J. Laight (ORCID: https://orcid.org/0000-0002-0371-3335)
- David M. Berman (ORCID: https://orcid.org/0000-0001-5985-3698)
- Charles H. Graham (ORCID: https://orcid.org/0000-0002-7014-8639)
- Sameh Basta (ORCID: https://orcid.org/0000-0002-3377-151X)
- Victoria Hoskin (ORCID: https://orcid.org/0000-0003-3525-1144)
- Ami Wang (ORCID: https://orcid.org/0000-0002-4143-2657)
- Andrew W. Craig (ORCID: https://orcid.org/0000-0002-2039-2393)
- Jacob Kment
- Richard W. Nauman
- Changnian Shi
- Іван Шаповалов
- Julian Simonetti
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- Queen's University (CA)
- Cancer Genetics (United States) (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3686
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Cancer Society
- Physicians' Services Incorporated Foundation
- Canadian Institutes of Health Research