High level of soluble tumor necrosis factor receptors is associated with lower residual diuresis volume in patients on hemodialysis: An exploratory study

This study supports the hypothesis that higher systemic levels of sTNFR1 may deteriorate residual renal function, as evidenced by the lower residual diuresis volume observed in patients on hemodialysis. These findings suggest that interventions aimed at reducing systemic inflammation may be beneficial in preserving residual renal function and improving clinical outcomes in these patients. Chronic Kidney Disease (CKD) is characterized by any persistent alteration or abnormality in kidney structure or function lasting over ninety days [1]. CKD's subtle onset complicates diagnosis, and once established, it often progresses irreversibly [2]. Recognized globally as a major public health issue [3], CKD affects 10-13% of adults in economically advanced countries [1]. In Brazil, CKD poses significant healthcare challenges, causing over 35,000 deaths annually and incurring substantial treatment costs [4]. Projections indicate around 10 million CKD cases in Brazil, with about 90,000 individuals requiring dialysis [5,6]. This data underscores the urgent need to address CKD as a critical health challenge and develop comprehensive strategies to mitigate its impact on public health and healthcare costs.

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Publication Details

Journal
PLoS ONE
Published
2025-04-29
DOI
https://doi.org/10.1371/journal.pone.0320019
Citations
1
Primary Topic
Dialysis and Renal Disease Management
Type
article
Field-Weighted Citation Impact
1.43
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article

High level of soluble tumor necrosis factor receptors is associated with lower residual diuresis volume in patients on hemodialysis: An exploratory study

Danúbia da Cunha de Sá-Caputo, Redha Taı̈ar, Gabriele Teixeira Gonçalves, Jousielle Márcia dos Santos et al.
1 citations
PLoS ONE
Dialysis and Renal Disease Management
1.43
article

High level of soluble tumor necrosis factor receptors is associated with lower residual diuresis volume in patients on hemodialysis: An exploratory study

Danúbia da Cunha de Sá-Caputo, Redha Taı̈ar, Gabriele Teixeira Gonçalves, Jousielle Márcia dos Santos, Vanessa Pereira Lima, Fidelis Antônio da Silva, Joyce Noelly Vítor Santos, Borja Sañudo, Luciana Martins de Mello Santos, Emílio Henrique Barroso Maciel, Vanessa Amaral Mendonça, Jaqueline de Paula Chaves Freitas, Frederico Lopes Alves, Vanessa Gomes Brandão, Mário Bernardo-Filho, Henrique Silveira Costa, Ana Cristina Rodrigues Lacerda, Maria Cecília Sales Mendes Prates, Victor Lacerda Gripp
article en
1 citations

Abstract

This study supports the hypothesis that higher systemic levels of sTNFR1 may deteriorate residual renal function, as evidenced by the lower residual diuresis volume observed in patients on hemodialysis. These findings suggest that interventions aimed at reducing systemic inflammation may be beneficial in preserving residual renal function and improving clinical outcomes in these patients. Chronic Kidney Disease (CKD) is characterized by any persistent alteration or abnormality in kidney structure or function lasting over ninety days [1]. CKD's subtle onset complicates diagnosis, and once established, it often progresses irreversibly [2]. Recognized globally as a major public health issue [3], CKD affects 10-13% of adults in economically advanced countries [1]. In Brazil, CKD poses significant healthcare challenges, causing over 35,000 deaths annually and incurring substantial treatment costs [4]. Projections indicate around 10 million CKD cases in Brazil, with about 90,000 individuals requiring dialysis [5,6]. This data underscores the urgent need to address CKD as a critical health challenge and develop comprehensive strategies to mitigate its impact on public health and healthcare costs.

PLoS ONEVol. 20(4)
Santa Casa Hospital (BR), Universidade do Estado do Rio de Janeiro (BR), Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR), Universidad de Sevilla (ES), Université de Reims Champagne-Ardenne (FR)
Good health and well-being
Openalex Percentile: Top 20%
Dialysis and Renal Disease Management
1.43
DOIOpen Access PDFOpenAlex
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