Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity
Z myristoylation and oligomerization are not required for its inhibitory vRNP activity. Targeting Z myristoylation with NMTi impairs virus assembly and budding without affecting Z-mediated inhibition of vRNP activity, supporting the development of NMTi as a promising broad-spectrum antiviral strategy against mammarenaviruses.
Authors
- Haydar Witwit (ORCID: https://orcid.org/0000-0002-0174-8454)
- Juan Carlos de la Torre (ORCID: https://orcid.org/0000-0002-8171-8115)
Institutions
- Scripps Research Institute (US)
Publication Details
- Journal
- BioChem
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/biochem5020010
- Citations
- 4
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases