Unveiling gastric precancerous stages: metabolomic insights for early detection and intervention
We used ultra-high-performance liquid chromatography with tandem mass spectrometry to effectively characterize metabolomic profiles in clinical gastric tissue samples. Key metabolites were identified and validated using targeted metabolomics. This study identified the metabolomic profiles of gastric tissues with atrophy and intestinal metaplasia of the gastric mucosa, uncovering and preliminarily validating key metabolites that may be used to assess high-risk populations and diagnose GPL, potentially advancing targeted gastric cancer prevention and treatment efforts.
Authors
- Yingyue Sheng (ORCID: https://orcid.org/0000-0002-2295-4310)
- Chen-yu Ma (ORCID: https://orcid.org/0009-0004-5996-1241)
- Yuzheng Xue (ORCID: https://orcid.org/0000-0003-1020-7059)
- Boyan Xu (ORCID: https://orcid.org/0000-0003-1327-4740)
- Yilin Ren (ORCID: https://orcid.org/0000-0001-6339-8579)
- Xiaoyue Zhang (ORCID: https://orcid.org/0000-0001-7922-2236)
- Bo Jiang (ORCID: https://orcid.org/0009-0000-9929-9943)
- Yan Geng (ORCID: https://orcid.org/0009-0008-2658-7598)
- Yuanyuan Dai (ORCID: https://orcid.org/0000-0001-6487-7803)
- Ziming Lin
Institutions
- Jiangnan University (CN)
- Wuxi Fourth People's Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12876-025-03898-9
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province