Effects of in vitro combination therapy with polymyxin B on delaying resistance in Klebsiella pneumoniae and insights into the mechanisms of polymyxin-induced resistance
nlpE contributes to PMB resistance by modulating the AcrAB-TolC efflux pump and the PhoP/Q and PmrA/B two-component systems. The combined use of PMB with AMK effectively delays the development of resistance in K. pneumoniae through the regulation of nlpE and its associated signalling pathways.
Authors
- Feng Wei (ORCID: https://orcid.org/0000-0003-1825-5354)
- Qian Yan (ORCID: https://orcid.org/0009-0008-7483-0572)
- Huanhuan Zhang (ORCID: https://orcid.org/0000-0002-2255-4261)
- Te Xu
- Fengjun Sun (ORCID: https://orcid.org/0000-0003-2679-8797)
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.jgar.2025.04.009
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18