Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis
Our findings unveil distinctive and actionable molecular signatures, offering deeper insights into the intricate cross-talk between tumor cells and stromal microenvironments enabling PM in colorectal cancer.
Authors
- Kristiaan Lenos (ORCID: https://orcid.org/0000-0003-1165-8732)
- Maarten F. Bijlsma (ORCID: https://orcid.org/0000-0001-6627-3229)
- Ryan Yong Kiat Tay (ORCID: https://orcid.org/0000-0002-9773-411X)
- Xuewen Ong
- Patrick Tan (ORCID: https://orcid.org/0000-0002-0179-8048)
- Wei Peng Yong (ORCID: https://orcid.org/0000-0003-4404-3777)
- Takeshi Hagihara (ORCID: https://orcid.org/0009-0007-9263-1553)
- Yvonne Tay (ORCID: https://orcid.org/0000-0003-4989-9101)
- Clara Y.L. Chong (ORCID: https://orcid.org/0000-0001-6796-9914)
- Tony Kiat Hon Lim (ORCID: https://orcid.org/0000-0003-0645-5164)
- Marcello Guagliò (ORCID: https://orcid.org/0000-0002-8194-9810)
- Joseph Jonathan Zhao (ORCID: https://orcid.org/0000-0002-2002-5390)
- Kie Kyon Huang (ORCID: https://orcid.org/0000-0003-4104-8951)
- Jia-Ying Joey Lee (ORCID: https://orcid.org/0000-0002-0420-7098)
- Robert Walsh (ORCID: https://orcid.org/0000-0003-0985-606X)
- Jolene Si Min Wong (ORCID: https://orcid.org/0000-0002-9750-5755)
- Louis Vermeulen (ORCID: https://orcid.org/0000-0002-6066-789X)
- Lit‐Hsin Loo (ORCID: https://orcid.org/0000-0001-6303-9840)
- Qiu Xuan Tan (ORCID: https://orcid.org/0000-0002-5700-1739)
- Huey Yew Jeffrey Lum (ORCID: https://orcid.org/0000-0002-3513-2404)
- Xiaonan Fan (ORCID: https://orcid.org/0000-0003-3308-2201)
- Raghav Sundar (ORCID: https://orcid.org/0000-0001-9423-1368)
- Chin Jin Seo
- Josephine Hendrikson (ORCID: https://orcid.org/0000-0002-2051-4063)
- Federica Morano (ORCID: https://orcid.org/0000-0002-5306-3596)
- Joey Wee‐Shan Tan (ORCID: https://orcid.org/0000-0001-6620-6085)
- Samuel Jacob Klempner (ORCID: https://orcid.org/0000-0002-4062-0808)
- Gillian Ng
- Craig Ryan Joseph (ORCID: https://orcid.org/0009-0004-5326-9692)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Chin‐Ann Johnny Ong (ORCID: https://orcid.org/0000-0003-4573-7738)
- Daryl Kai Ann Chia (ORCID: https://orcid.org/0000-0001-9936-1225)
- Haoran Ma (ORCID: https://orcid.org/0009-0004-9614-1832)
- Claramae S. Chia
- Su Ting Tay (ORCID: https://orcid.org/0000-0003-3609-0143)
- Ying Liu (ORCID: https://orcid.org/0000-0002-4726-7816)
- Wanyu Guo
- Taotao Sheng (ORCID: https://orcid.org/0000-0003-3809-4885)
- Mingzhe Cai (ORCID: https://orcid.org/0000-0002-0561-7312)
- Supriya Srivastava (ORCID: https://orcid.org/0000-0002-6727-3076)
- Joe Poh-Sheng Yeong (ORCID: https://orcid.org/0000-0002-6674-7153)
- Ming Teh (ORCID: https://orcid.org/0000-0001-6879-8678)
- Li Yen Chong (ORCID: https://orcid.org/0000-0002-4623-4633)
- Angie Lay Keng Tan (ORCID: https://orcid.org/0000-0002-8238-0515)
- Melissa Teo
- Kevin M.S. Sim
- Ying En Quek
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Singapore General Hospital (SG)
- Dutch Cancer Society (NL)
- Singapore Immunology Network (SG)
- Yale University (US)
- Massachusetts General Hospital (US)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- National University Cancer Institute, Singapore (SG)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- National University Hospital (SG)
- National Heart Centre Singapore (SG)
- National University Health System (SG)
- Amsterdam University Medical Centers (NL)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Stichting Roomsch Catholyk Oude Armen kantoor (NL)
- Institute of Molecular and Cell Biology (SG)
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3780
- Citations
- 4
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 8.03