Amplification of Extrachromosomal <i>MYC</i> Paralogs Shapes Immunosuppressive Tumor Microenvironment in Small Cell Lung Cancer
Extrachromosomal amplification of MYC paralogs shapes the suppressive tumor immune microenvironment, identifying potential subgroups of immunotherapy-resistant patients.
Authors
- Mantang Qiu (ORCID: https://orcid.org/0000-0002-0419-9139)
- Jianqi She (ORCID: https://orcid.org/0000-0001-7210-6638)
- Xiao Li (ORCID: https://orcid.org/0000-0002-0455-0355)
- Fan Yang (ORCID: https://orcid.org/0000-0002-1044-7821)
- Jiaming Deng (ORCID: https://orcid.org/0009-0005-7654-3612)
- Zhijian Liang (ORCID: https://orcid.org/0009-0005-3918-7129)
- Yueqi Jin (ORCID: https://orcid.org/0000-0003-0225-6512)
- Ence Yang (ORCID: https://orcid.org/0000-0002-9526-2737)
- Xueyan Hu (ORCID: https://orcid.org/0000-0002-4253-3564)
- Jian Chen (ORCID: https://orcid.org/0000-0002-0438-7631)
- Jun Wang (ORCID: https://orcid.org/0000-0002-7033-5012)
- Yan Ju (ORCID: https://orcid.org/0009-0004-5667-0617)
- Kunkun Sun (ORCID: https://orcid.org/0000-0002-4530-5778)
- Jingwei Zhang (ORCID: https://orcid.org/0000-0002-9808-0971)
- Haodong Lin (ORCID: https://orcid.org/0009-0008-9746-275X)
- Kongxu Dai (ORCID: https://orcid.org/0009-0000-7724-2225)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Chinese Institute for Brain Research (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3399
- Citations
- 10
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.45