Chronic active and chronic inactive hepatitis B virus infection: Comparative study of genetic polymorphism and blood profile measures
The TLR3 1377 C/T polymorphism, particularly the CC genotype, may influence the clinical presentation of chronic hepatitis B, particularly in symptomatic cases. However, its impact on HBeAg status and overall chronicity appears limited. Further studies are needed to clarify the role of TLR3 polymorphisms in HBV pathogenesis and their potential as therapeutic targets.
Authors
- Jaber Alfaifi (ORCID: https://orcid.org/0000-0002-4507-3970)
- Abdelsalam MA Nail
- Ahmed Soliman Doghish (ORCID: https://orcid.org/0000-0002-0136-7096)
- Mohamed E. Elnageeb (ORCID: https://orcid.org/0000-0002-7191-1675)
- Nadir Abuzeid (ORCID: https://orcid.org/0000-0003-2074-7892)
- Elsadig Mohamed Ahmed (ORCID: https://orcid.org/0000-0002-5027-7206)
- Abdullah Hassan Alhalafi (ORCID: https://orcid.org/0000-0002-8273-0693)
- Ali M. S. Eleragi (ORCID: https://orcid.org/0000-0001-6475-6382)
- Osama A. Mohammed (ORCID: https://orcid.org/0000-0001-9712-9609)
- Najem Aldin M Osman (ORCID: https://orcid.org/0000-0002-0763-0334)
- Khalid Elyass Awadelkarim
Institutions
- University of Medical Sciences and Technology (SD)
- Al-Azhar University (EG)
- Omdurman Islamic University (SD)
- University of Bisha (SA)
- Badr University in Cairo (EG)
- Sudan University of Science and Technology (SD)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1371/journal.pone.0322268
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00