Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer
Our multi-omics approach yields novel insights into the molecular underpinnings of EOCRC and we characterize the role of PIWIL1-associated piRNAs in modulating EOCRC metastasis and invasion. FR019089 shows promise as a prognostic biomarker with potential clinical utility in the risk stratification and management of EOCRC patients.
Authors
- Malcolm G. Dunlop (ORCID: https://orcid.org/0000-0002-3033-5851)
- Qian Xiao (ORCID: https://orcid.org/0000-0002-0120-2371)
- Evropi Τheodoratou (ORCID: https://orcid.org/0000-0001-5887-9132)
- Jing Sun (ORCID: https://orcid.org/0000-0003-0046-6663)
- Honghe Zhang (ORCID: https://orcid.org/0000-0001-5954-2857)
- Kefeng Ding (ORCID: https://orcid.org/0000-0002-2380-3717)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-7885-9945)
- Siyun Zhou
- Xue Li (ORCID: https://orcid.org/0000-0002-8633-6087)
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-9365-7460)
- Yadong Lu
- Jianhui Zhao (ORCID: https://orcid.org/0000-0001-7605-5268)
- Lili Yu (ORCID: https://orcid.org/0000-0002-3010-3727)
Institutions
- Edinburgh Cancer Research (GB)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
- Medical Research Council (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12916-025-04074-2
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- National Natural Science Foundation of China
- Zhejiang University
- National Science and Technology Major Project