Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway
Collectively, EPS attenuates oxidative stress and mitochondrial dysfunction by directly binding KEAP1 to activate the KEAP1/Nrf2 signaling pathway, further reducing DAergic neurons damage. These findings suggest that EPS has great potential to become a therapeutic for PD as a clinically effective and safe medicine.
Authors
- Hong Jiang (ORCID: https://orcid.org/0000-0002-9610-6410)
- K. J. Ren (ORCID: https://orcid.org/0009-0003-3500-4001)
- Fengyuan Che (ORCID: https://orcid.org/0000-0003-1278-5899)
- Xi Chen (ORCID: https://orcid.org/0000-0003-4257-7820)
- Zhen Qiao (ORCID: https://orcid.org/0000-0003-4682-0963)
- Mengru Liu (ORCID: https://orcid.org/0000-0003-0856-7223)
- Xixun Du (ORCID: https://orcid.org/0000-0003-0243-2993)
- Qian Jiao (ORCID: https://orcid.org/0009-0003-0576-8297)
- Huafang Jia
Institutions
- Qingdao University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12974-025-03455-x
- Citations
- 6
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province