Vaccine Effectiveness in SARS-CoV-2-Infected Pregnant Women with Gestational Diabetes Mellitus: Results from a Multicenter Registry-Based Prospective Cohort Study in Germany

<b>Introduction</b> COVID-19 in pregnancy is associated with increased maternal and neonatal morbidity and mortality. The aim of our study was to investigate the effectiveness of COVID-19 vaccination in SARS-CoV-2-infected pregnant women with focus on women with gestational diabetes mellitus on pregnancy outcomes. <b>Patients and Methods</b> COVID-19 Obstetric and Neonatal Outcome study is a multicenter prospective observational study which registered SARS-CoV-2-infected pregnant women from April 2020 to December 2022. In March 2021, the study was complemented by the SATELLITES study which recruited vaccinated women until September 2023. Primary composite maternal and neonatal endpoints were defined. Multivariate adjusted logistic regression analysis was performed to evaluate the impact of vaccination on pregnancy outcomes. Vaccine effectiveness was defined as (1-adjusted odds ratio)*100. <b>Results</b> We registered 10 386 pregnant women, 6112 of whom were analyzed. 30% of women were vaccinated against COVID-19. Vaccination in women with gestational diabetes mellitus was associated with a vaccine effectiveness of 75% (95% CI: 16 - 93), depending on the predominant virus variant, and of 67% in the total cohort (95% CI: 36 - 83). No statistically significant difference was found in vaccine effectiveness with regards to perinatal outcomes of women with gestational diabetes mellitus (16%; 95% CI -58 - 55) but there was an impact in the total cohort (26%; 95% CI 8 - 94). <b>Conclusion</b> For pregnant women with gestational diabetes mellitus who were infected with SARS-CoV-2, at least one vaccination against COVID-19 before or during pregnancy was independently associated with a milder course of COVID-19 in mothers compared to no vaccination. We found no evidence of improved perinatal outcomes. The data emphasize the benefits of vaccination before or during pregnancy.

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Publication Details

Journal
Geburtshilfe und Frauenheilkunde
Published
2025-04-29
DOI
https://doi.org/10.1055/a-2576-6293
Citations
1
Primary Topic
COVID-19 Impact on Reproduction
Type
article
Field-Weighted Citation Impact
2.06

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article

Vaccine Effectiveness in SARS-CoV-2-Infected Pregnant Women with Gestational Diabetes Mellitus: Results from a Multicenter Registry-Based Prospective Cohort Study in Germany

Michael K. Bohlmann, Mandy Mangler, Lydia Remtisch, Helmut Kleinwechter et al.
1 citations
Geburtshilfe und Frauenheilkunde
COVID-19 Impact on Reproduction
2.06
article

Vaccine Effectiveness in SARS-CoV-2-Infected Pregnant Women with Gestational Diabetes Mellitus: Results from a Multicenter Registry-Based Prospective Cohort Study in Germany

Michael K. Bohlmann, Mandy Mangler, Lydia Remtisch, Helmut Kleinwechter, Eike A. Strathmann, Nadine Mand, Katharina Susanne Weber, Ute M. Schaefer-Graf, Janine Zöllkau, Dietmar Schlembach, Mario Rüdiger, Ulrich Pecks, Katharina Weizsäcker, Bettina Kuschel, Antonella Iannaccone, Mirjam Kunze, Iris Dressler‐Steinbach, Linda Wegner, Kristin Reinhardt, Kristin Andresen, V. Meister, Sophia Ajouby, Katharina Rathberger, Babett Ramsauer, Feline Wowretzko, Peter Jakubowski, Kathleen M. Oberste
article en
1 citations

Abstract

<b>Introduction</b> COVID-19 in pregnancy is associated with increased maternal and neonatal morbidity and mortality. The aim of our study was to investigate the effectiveness of COVID-19 vaccination in SARS-CoV-2-infected pregnant women with focus on women with gestational diabetes mellitus on pregnancy outcomes. <b>Patients and Methods</b> COVID-19 Obstetric and Neonatal Outcome study is a multicenter prospective observational study which registered SARS-CoV-2-infected pregnant women from April 2020 to December 2022. In March 2021, the study was complemented by the SATELLITES study which recruited vaccinated women until September 2023. Primary composite maternal and neonatal endpoints were defined. Multivariate adjusted logistic regression analysis was performed to evaluate the impact of vaccination on pregnancy outcomes. Vaccine effectiveness was defined as (1-adjusted odds ratio)*100. <b>Results</b> We registered 10 386 pregnant women, 6112 of whom were analyzed. 30% of women were vaccinated against COVID-19. Vaccination in women with gestational diabetes mellitus was associated with a vaccine effectiveness of 75% (95% CI: 16 - 93), depending on the predominant virus variant, and of 67% in the total cohort (95% CI: 36 - 83). No statistically significant difference was found in vaccine effectiveness with regards to perinatal outcomes of women with gestational diabetes mellitus (16%; 95% CI -58 - 55) but there was an impact in the total cohort (26%; 95% CI 8 - 94). <b>Conclusion</b> For pregnant women with gestational diabetes mellitus who were infected with SARS-CoV-2, at least one vaccination against COVID-19 before or during pregnancy was independently associated with a milder course of COVID-19 in mothers compared to no vaccination. We found no evidence of improved perinatal outcomes. The data emphasize the benefits of vaccination before or during pregnancy.

Geburtshilfe und FrauenheilkundeVol. 85(10)
University of Freiburg (DE), Philipps University of Marburg (DE), University of Würzburg (DE), University Medical Center Freiburg (DE), TUM Klinikum (DE), Christian-Albrechts-Universität zu Kiel (DE), Humboldt-Universität zu Berlin (DE), Asklepios Fachklinikum Brandenburg (DE), Auguste-Viktoria-Klinik (DE), Starnberg Hospital (DE), University Hospital Münster (DE), St. Elisabeth-Hospital Bochum (DE), Vivantes Klinikum (DE), University Hospital Schleswig-Holstein (DE), Olgahospital (DE), Essen University Hospital (DE), Krankenhaus Barmherzige Brüder (DE), University Hospital Leipzig (DE), Universitätsklinikum Würzburg (DE), Jena University Hospital (DE), St. Joseph-Krankenhaus (DE), St. Franziskus Hospital (DE), Deutsches Diabetes-Zentrum e.V. (DE), University Hospital Carl Gustav Carus (DE), Martin Luther University Halle-Wittenberg (DE), Freie Universität Berlin (DE), Technische Universität Dresden (DE), Charité - Universitätsmedizin Berlin (DE), University of Lübeck (DE)
Eli Lilly and Company
Openalex Percentile: Top 16%
COVID-19 Impact on Reproduction
2.06
DOIOpen Access PDFOpenAlex
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