Assessing osteopenia and osteoporosis with dual-energy x-ray absorptiometry studies in Fabry disease
The findings of this cohort highlight the high prevalence of low bone mineral density in FD and correlations of low Z and T- scores with elevated levels of Lyso-GL3, and low calcium levels. We did not find correlations with renal function, and vitamin D levels. We discuss etiology, prevention, and treatment strategies for osteopenia/osteoporosis in Fabry disease.
Authors
- Kathy Hall
- Mania Mgdsyan (ORCID: https://orcid.org/0000-0001-7954-899X)
- Angela Martin-Rios
- Nadia Sadri
- Virginia Kimonis (ORCID: https://orcid.org/0000-0003-1567-4449)
- Madeleine V. Pahl
- Kelsey Valentine
- Alyaa Shmara (ORCID: https://orcid.org/0000-0001-8667-6754)
- Lynda E. Polgreen
- Grace Lee (ORCID: https://orcid.org/0000-0001-7892-2871)
- Tatiana S. Kain
Institutions
- Florida State University (US)
- University of California, Irvine (US)
- UCLA Medical Center (US)
- University of California, Irvine Medical Center (US)
- Irvine University (US)
- Colorado Kidney Care (US)
- Harbor–UCLA Medical Center (US)
- New York University (US)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13023-025-03601-x
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Sanofi Genzyme