SAT-044 Differences across age, gender and therapy in Colombian patients withacromegaly: A retrospective study.

Abstract A. Abreu Lomba: None. M. Patiño Arboleda: None. D. Aristizabal Colorado: None. N. Buitrago Gomez: None. R. Carvajal Ortiz: None. D.A. Vernaza Trujillo: None. A. Pinzón Tovar: None. Objective: Determine clinical differences across age and gender in Colombian patients with acromegaly. Methods: Observational, analytical, multicenter, retrospective cohort study based on a national registry of patients with acromegaly in Colombia. The data gathered comprised sociodemographic, clinical, and treatment referent variables at the entry of the registry and for control at six months after the adjustment of therapeutic management. Results: 201 patients from the RAPACO cohort (60% women and 75% under 60 years old) were included. The average weight was 75.1 kg and the height was 1.63 m, being higher in men and under 60 years old. The average time of evolution of the disease until diagnosis was 6.9 years, with no differences concerning gender. Macroadenoma was the most common type of tumor, presented in 78% of cases. In the clinical differences, after classic symptoms of acromegaly, decreased libido was found more frequently in men, and depression was a significant symptom in those men over 60years old. Arterial hypertension and colonic and hepatobiliary pathology were more prevalent in women. Cardiomyopathy, hypertension, and bone pathology (osteoporosis and osteopenia) were more frequent among people over 60 years old. The most used initial treatment was surgical intervention and medical guidance for individuals between the ages of 18 and 60. The combination of medical management and surgical intervention was the option that was associated with enhanced clinical control. Conclusion: In Colombian patients with acromegaly, men had higher decreased libido. In women, the proportion of comorbidities as with hypertension, colonic and hepatobiliary pathology were more common. By age group, those under 60 years had higher anthropometric parameters. In individuals over 60 years old, depression was a significant clinical manifestation, and cardiomyopathy, hypertension, and bone pathology were more prevalent. In our study were no differences in disease control by gender or age group; and the medical treatment was associated with greater disease control. Saturday, June 1, 2024