Inverse association of healthy diet scores with non-alcoholic fatty liver disease among Chinese patients with type 2 diabetes mellitus

We aimed to investigate the association of healthy diet scores (HDS), comprising major components (fruits and vegetables, soybean, fish, and sugar-sweetened beverages), with non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). In this cross-sectional study of 2,404 T2DM individuals aged 35-70 years, individuals with higher HDS (≥3 components) had a lower odds of NAFLD (adjusted odds ratio [OR]: 0.64; 95% confidence interval [CI]: 0.48, 0.84) and lower fatty liver index (FLI) levels (β: -4.70; 95% CI: -7.61, -1.79). Each one-component increase in HDS was associated with a 14% reduction in the odds of NAFLD (OR: 0.86; 95% CI: 0.75, 0.98) and a 1.95-unit reduction in FLI levels (β: -1.95; 95% CI: -3.21, -0.70). These results suggest that adherence to a higher HDS pattern may be protective against NAFLD in T2DM.

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Publication Details

Journal
International Journal of Food Sciences and Nutrition
Published
2025-04-29
DOI
https://doi.org/10.1080/09637486.2025.2499042
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Inverse association of healthy diet scores with non-alcoholic fatty liver disease among Chinese patients with type 2 diabetes mellitus

Yingqian Li, John Cai, Wei Chen, Lin-Jia Du et al.
International Journal of Food Sciences and Nutrition
Liver Disease Diagnosis and Treatment
article

Inverse association of healthy diet scores with non-alcoholic fatty liver disease among Chinese patients with type 2 diabetes mellitus

Yingqian Li, John Cai, Wei Chen, Lin-Jia Du, Li-Juan Yang, Xiang Hu, Bo Yang, Lin-Yu Pan, Zhiying He, Yuhua Wang, Jing Li, Xingxing Zhang, Gu Xiao, Huimin Xia, Siyu Gao, Xuejiang Gu
article en

Abstract

We aimed to investigate the association of healthy diet scores (HDS), comprising major components (fruits and vegetables, soybean, fish, and sugar-sweetened beverages), with non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). In this cross-sectional study of 2,404 T2DM individuals aged 35-70 years, individuals with higher HDS (≥3 components) had a lower odds of NAFLD (adjusted odds ratio [OR]: 0.64; 95% confidence interval [CI]: 0.48, 0.84) and lower fatty liver index (FLI) levels (β: -4.70; 95% CI: -7.61, -1.79). Each one-component increase in HDS was associated with a 14% reduction in the odds of NAFLD (OR: 0.86; 95% CI: 0.75, 0.98) and a 1.95-unit reduction in FLI levels (β: -1.95; 95% CI: -3.21, -0.70). These results suggest that adherence to a higher HDS pattern may be protective against NAFLD in T2DM.

International Journal of Food Sciences and NutritionVol. 76(4)
Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN)
Chinese Nutrition Society, National Natural Science Foundation of China, Natural Science Foundation of Zhejiang Province
Zero hunger
Openalex Percentile: Top 87%
Liver Disease Diagnosis and Treatment
DOISourceOpenAlex
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