Ginsenoside Re increases human coronary artery endothelial SKCa current and nitric oxide release via glucocorticoid receptor-PI3K-Akt/PKB pathway
Re enhances SK<sub>Ca</sub> current and NO production via GR-PI3K-Akt/PKB and eNOS activation; in turn, SK<sub>Ca</sub> current is essential for Re-increased NO. However, Re-induced PGI<sub>2</sub> release is independent of SK<sub>Ca</sub> current. These findings could facilitate further research about ginseng effects on coronary artery and possible use in cardiovascular diseases.
Authors
- Wattana B. Watanapa (ORCID: https://orcid.org/0000-0001-6206-4980)
- Namoiy Semprasert
- Suwattanee Kooptiwut (ORCID: https://orcid.org/0000-0003-4072-1438)
- Katesirin Ruamyod
- Pimchanok Nambundit
- Kitinat Rodthongdee
- Luecha Boontaveekul
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Naresuan University (TH)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.jgr.2025.04.008
- Citations
- 3
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.42