Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation
Senescent cells, including neochondrocytes, are abundant within inferior repair tissue following marrow stimulation. While their fibrogenic SASP is associated with poor healing, their removal after senescence induction does not improve repair tissue quality, possibly due to the lack of a replacement chondrogenic population.
Authors
- Intawat Nookaew (ORCID: https://orcid.org/0000-0001-8901-1088)
- Luke Childress
- Ryan M. Porter (ORCID: https://orcid.org/0000-0002-0246-5747)
- Landon B. Gatrell
- Elisabeth Ferreira (ORCID: https://orcid.org/0000-0003-0065-6862)
- Hong Wu (ORCID: https://orcid.org/0000-0001-7066-8039)
Institutions
- University of Arkansas Medical Center (US)
- Arkansas Department of Agriculture (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100620
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00