LPM electrode loaded with RAPA-PLGA drug sustained-release system can reduce local fibrous tissue hyperplasia and local bioelectrical impedance
The LPM electrode loaded with RAPA-PLGA demonstrates significant, sustained drug release and anti-proliferative effects in vitro. This drug-loaded electrode has been deemed safe for implantation in animal models. It can effectively inhibit local fibrous tissue proliferation and reduce local bioelectrical impedance, offering a technical strategy to prolong the in vivo functionality of LPMs and enhance clinical procedures.
Authors
- Ahsan Riaz Khan (ORCID: https://orcid.org/0000-0001-9683-4728)
- Wentao Du (ORCID: https://orcid.org/0000-0002-5522-148X)
- Tao Wang (ORCID: https://orcid.org/0000-0003-4045-2434)
- Haijun Zhang (ORCID: https://orcid.org/0000-0002-3686-6346)
- Yunyun Wang (ORCID: https://orcid.org/0000-0002-0102-9898)
Institutions
- Hebei University of Engineering (CN)
- Tongji University (CN)
- Shanghai Tenth People's Hospital (CN)
- Cat Tien National Park (VN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s40001-025-02619-y
- Primary Topic
- Advanced Sensor and Energy Harvesting Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China