Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories

This study did not find evidence to support using aCG to predict carboplatin clearance better than CG. However, cystatin C was found to be the most precise and accurate biomarker for carboplatin clearance.

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Institutions

Publication Details

Journal
Therapeutic Drug Monitoring
Published
2025-04-29
DOI
https://doi.org/10.1097/ftd.0000000000001328
Citations
2
Primary Topic
Chemotherapy-induced organ toxicity mitigation
Type
article
Field-Weighted Citation Impact
2.94
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article

Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories

Mart P. Kicken, Rob ter Heine, Dirk-Jan A. R. Moes, P. Margreet G. Filius et al.
2 citations
Therapeutic Drug Monitoring
Chemotherapy-induced organ toxicity mitigation
2.94
article

Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories

Mart P. Kicken, Rob ter Heine, Dirk-Jan A. R. Moes, P. Margreet G. Filius, Hans J.M. Smit, Theo van Voorthuizen, Kaat Beunen, Peter J. de Jong, C. Bethlehem, Maarten J. Deenen, Matthijs van Luin, Jeanine J. van den Hudding
article en
2 citations

Abstract

This study did not find evidence to support using aCG to predict carboplatin clearance better than CG. However, cystatin C was found to be the most precise and accurate biomarker for carboplatin clearance.

Therapeutic Drug MonitoringVol. 47(6)
Radboud University Nijmegen (NL), Leiden University Medical Center (NL), Catharina Ziekenhuis (NL), Erasmus MC (NL), Radboud University Medical Center (NL), Rijnstate Hospital (NL), Meander Medisch Centrum (NL)
Good health and well-being
Openalex Percentile: Top 10%
Chemotherapy-induced organ toxicity mitigation
2.94
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Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories — Mart P. Kicken, Rob ter Heine, et al. · Therapeutic Drug Monitoring (2025) | TGRS Research Map | TGRS