Synthesis and Crystal Structure as well as Cytotoxicity Analysis of Dichloro-Terpyridine-Copper Complex

Malignant tumors, recognized as one of the most threatening diseases of the 20th century, continue to exhibit a rising incidence trend in the 21st century. Against this backdrop, metal complexes have attracted considerable attention due to their unique antitumor activities. In this study, we unexpectedly obtained a copper-based complex coordinated with 2,2':6',2''-Terpyridine and chloride anion ligands, and characterized its crystal structure using X-ray single-crystal diffraction technique. The cytotoxic effects of this metal complex against various tumor cell lines were evaluated through MTT assays, and the findings provide significant theoretical and practical foundations for developing novel anticancer drugs.