Extraction of Chondroitin Sulfate and Its Current Use

Chondroitin sulfate (CS) is a polyanionic polymer compound. It is an acidic mucopolysaccharide. These compounds are commonly found in the nasal bone, trachea, leg bone, hyoid bone and other parts of mammals, and are the main components of connective tissues such as cartilage, muscle membrane, blood vessel wall and skin. China is the country with the largest amount of livestock slaughtered in the world. However, a large number of animal bones are currently discarded and not fully utilized. Based on this situation, this project used bovine nasal cartilage as the source of chondroitin sulfate. Chondroitin sulfate was extracted by a complex, but simple enzymatic method with high extraction efficiency. In addition, it is well known that chondroitin sulfate also has various pharmacological activities such as anti-inflammatory, antitumor, etc. It is currently used clinically for the prevention and treatment of osteoarthritis, cardiovascular and cerebrovascular diseases. Therefore, this paper also collates and summarizes its clinical and biomedical uses.