Ceftriaxone induced neurotoxicity: a word of caution for elderly and patients with renal impairment

Ceftriaxone is a third-generation cephalosporin commonly used in inpatient settings and is associated with both hepatic and renal excretion. The cephalosporin group, particularly the fourth generation, including cefepime, has been commonly associated with encephalopathy, but recent literature has also suggested an increasing trend of encephalopathy related to ceftriaxone.