Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury
Pupil abnormalities are common across TBI severities, particularly in severe cases. A higher frequency of abnormal pupil measurements within the first 72 hours is associated with unfavorable outcomes and significantly enhances the predictive performance of established TBI prognostic models. Serial quantitative pupillometry may offer clinically valuable, dynamic prognostic information in the acute care setting.
Authors
- Emily J. Gilmore (ORCID: https://orcid.org/0000-0002-4659-6861)
- Andrew Reinert
- Chuong Nguyen (ORCID: https://orcid.org/0000-0001-8373-981X)
- Mohamad K. Abdalkader (ORCID: https://orcid.org/0000-0002-9528-301X)
- Ali Daneshmand (ORCID: https://orcid.org/0000-0001-7927-2030)
- Shariq Mohammed (ORCID: https://orcid.org/0000-0002-3107-2969)
- Josée Dupuis (ORCID: https://orcid.org/0000-0003-2871-3603)
- Charlene Ong (ORCID: https://orcid.org/0000-0003-2377-3025)
- David M. Greer (ORCID: https://orcid.org/0000-0002-2026-8333)
- Leigh Ann Mallinger
- So Yeon Kim (ORCID: https://orcid.org/0000-0001-5352-157X)
- Yili Du (ORCID: https://orcid.org/0000-0001-8444-5477)
- Kevin N. Sheth
- Divya Veerapaneni
- Naveen Arunachalam Sakthiyendran (ORCID: https://orcid.org/0009-0001-3445-5121)
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Yale University (US)
- Yale New Haven Health System (US)
- McGill University (CA)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1097/cce.0000000000001257
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39