Investigation of the Relationship of CRP/Albumin Ratio with Clinical Parameters, Prognosis and Physiotherapy in Amyotrophic Lateral Sclerosis CRP/Albumin Ratio in Amyotrophic Lateral Sclerosis

Aim: The aim of this study was to investigate relationship of onset CAR value with clinical parameters, post treatment functional capacity and physiotherapy effectiveness in patients with Amyotrophic Lateral Sclerosis (ALS). Method: Ethical approval was obtained for this study on June 16, 2023, with number E. Kurul-2023-21/751. This retrospective study was undertaken between January 2021 and January 2024. Forty-five patients whose blood test results, Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) score records and disease-related clinical findings were accessed through electronic patient report were included in study among 57 patients diagnosed with ALS. Forty-five healthy people of similar age and gender who attended check-up clinic without any complaints were included in study as a control group. Results: A total of 90 people, 45 patients with ALS and 45 healthy people as control group were included in study. The female/male ratio and mean age of both groups were similar and there was no statistical difference. The mean CAR of patients with ALS was 1.92±0.14, while mean CAR of control group 0.82±0,15 and there was no significant difference between groups in terms of mean CAR (p: 0.2). WBC and Neutrophil were significantly higher in ALS group according to control group (p:0.017, p:0.038). CAR was not found to correlate with clinical parameters of ALS and number of physiotherapy sessions received. Functional ambulation Scale scores were found to be higher as number of physical therapy sessions increased. Conclusion: This study is first to evaluate CAR in ALS patients. CAR measured at time of diagnosis of ALS disease was not significantly higher than control group, and we could not find a relationship between CAR and post treatment functional scores. However, CAR may be an important parameter, especially in evaluating malnutrition and chronic inflammation when disease progresses and complications develop.