<i>Para</i>‐Toluenesulfonic Acid‐Catalyzed Green Synthesis of Pyrazolo[1,5‐<i>a</i>]pyrimidines from 5‐Aminopyrazoles and Terminal Keto‐Alkynes
A simple and effective approach has been established for the synthesis of novel multi‐substituted pyrazolo[1,5‐ a ]pyrimidine derivatives utilizing 5‐amino‐pyrazoles and terminal keto‐alkynes as starting materials. This method achieves excellent yields under catalytic acidic conditions in environmentally benign solvents (water/ethanol) at ambient temperature. Moreover, this protocol affords NMR pure products through a simple filtration process. Additionally, the synthetic utility is validated through a gram‐scale synthesis of the biologically active tubulin inhibitor, 6 . Thereby emphasizing the pivotal role of chemistry in designing and producing potent anticancer molecules for therapeutic use.
Authors
- Ähmed Kamal (ORCID: https://orcid.org/0000-0002-4107-1775)
- Gal Reddy Potuganti (ORCID: https://orcid.org/0000-0002-1390-9526)
- Abdul Rahim (ORCID: https://orcid.org/0000-0003-1409-7619)
- Velma Ganga Reddy (ORCID: https://orcid.org/0000-0001-5054-2519)
- Divakar Reddy Indukuri
- Bathini Nagendra Babu (ORCID: https://orcid.org/0000-0001-7378-0878)
- Niggula Praveen Kumar
- Shaik Taj
Institutions
- Chaitanya Bharathi Institute of Technology (IN)
- University of Arizona (US)
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Bharat Biotech (India) (IN)
- Indian Institute of Chemical Technology (IN)
- Birla Institute of Technology and Science, Pilani (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1002/ejoc.202500098
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00