O USO DO PEELING QUÍMICO DE ÁCIDO MANDÉLICO NO TRATAMENTO DE HIPERCROMIAS PÓS INFLAMATÓRIA DE ACNE: REVISÃO INTEGRATIVA

Introduction: Acne is a multifactorial, genetic and inflammatory disorder, and post-inflammatory hyperpigmentation (PIH) is related to inflammation, such as acne and external factors. Objective: To understand the effect of mandelic acid chemical peeling in the treatment of post-inflammatory acne hyperpigmentation. Methods: An integrative literature review study was carried out. The bibliographic search was performed in the following databases: United States National Library of Medicine (PUBMED) and Google Scholar. The Health Sciences Descriptor (DeCS/MeSH) platform was used to select the articles with the following terms: “Hyperpigmentation OR Hyperpigmentation AND Mandelic Acid”, “Acne Vulgaris AND Mandelic Acid” and “Hyperpigmentation OR Hyperpigmentation AND Acne Vulgaris”. Initially, 578 studies were identified; after applying the inclusion and exclusion criteria, 5 studies were included in the search. Results: The five studies included in the analysis exposed the effect of mandelic acid chemical peeling in the treatment of post-inflammatory acne hyperchromia. Mandelic acid peeling acts by inhibiting melanin synthesis and removing pigments from the already formed stain. Conclusion: The study comprehensively analyzed the effect of mandelic acid chemical peeling in the treatment of post-inflammatory acne hyperchromia. Analyzing several studies with divergent methodologies, understanding the use of chemical peeling and the effects of mandelic acid, such as tyrosinase supplementation and safety in high phototypes, detailing the mechanism of action achieving the objectives of the study.