INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Monalizumab plus cetuximab did not improve OS compared with placebo plus cetuximab. The safety profile of the combination was consistent with safety observations for cetuximab monotherapy.
Authors
- Christian Sebastian Fuentes
- Lillian L. Siu (ORCID: https://orcid.org/0000-0002-3500-0540)
- Marcelo Raul Bonomi (ORCID: https://orcid.org/0000-0002-9399-3608)
- Tomoya Yokota (ORCID: https://orcid.org/0000-0001-7327-7949)
- Paul M. Clément (ORCID: https://orcid.org/0000-0001-7600-0806)
- Muh‐Hwa Yang
- Lúcia Águas
- Sacha I. Rothschild (ORCID: https://orcid.org/0000-0003-1304-9340)
- Martín Paskevicius
- Marek Z. Wojtukiewicz (ORCID: https://orcid.org/0000-0002-7604-8188)
- Stefan Kasper (ORCID: https://orcid.org/0000-0002-5947-8733)
- Tanguy Y. Seiwert (ORCID: https://orcid.org/0000-0001-7919-8272)
- Hui Kong Gan (ORCID: https://orcid.org/0000-0001-7319-8546)
- Makoto Tahara (ORCID: https://orcid.org/0000-0001-9035-3106)
- Justyna Rawluk
- Bogdan Żurawski
- Seong Hoon Shin
- Robert L. Metcalf
- С. И. Кутукова (ORCID: https://orcid.org/0000-0003-2221-4088)
- Jessica R. Bauman (ORCID: https://orcid.org/0000-0001-8691-0387)
- Lucas Vieira dos Santos (ORCID: https://orcid.org/0000-0002-2221-6692)
- Muneyuki Masuda (ORCID: https://orcid.org/0000-0002-7479-8356)
- Paolo Bossi (ORCID: https://orcid.org/0000-0003-0135-0224)
- Shunji Takahashi (ORCID: https://orcid.org/0000-0002-5031-1953)
- João Marcos Domingues Dias (ORCID: https://orcid.org/0000-0002-5660-4108)
- Rossitza Krasteva Ruseva
- Demetria I. Jacks
- Tsung-Ming Chen (ORCID: https://orcid.org/0000-0002-5462-1668)
- J. Marruecos Querol
- Michael J. Jelinek (ORCID: https://orcid.org/0000-0003-4959-2222)
- Sílvia Lopes (ORCID: https://orcid.org/0000-0002-6048-396X)
- Agustín Falco (ORCID: https://orcid.org/0000-0003-4487-2444)
- Sung‐Bae Kim (ORCID: https://orcid.org/0000-0001-5588-8332)
- Obiageli Uchenna Ogbata
- Philipp Ivanyi (ORCID: https://orcid.org/0000-0002-2862-7302)
- Charles Uy
- Jérôme Fayette (ORCID: https://orcid.org/0000-0002-8126-7019)
- Anirudha Dasgupta
- Chia‐Jui Yen (ORCID: https://orcid.org/0000-0001-8744-6248)
- Paweł Różanowski (ORCID: https://orcid.org/0000-0001-9179-6435)
- Maureen Bernadach (ORCID: https://orcid.org/0000-0002-7185-0809)
- Urs Müller‐Richter (ORCID: https://orcid.org/0000-0001-7869-7686)
- Dan Paul Zandberg (ORCID: https://orcid.org/0000-0002-1002-8301)
- Naomi Kiyota (ORCID: https://orcid.org/0000-0001-8021-6116)
- Myung‐Ju Ahn (ORCID: https://orcid.org/0000-0002-5740-9654)
- Charles Kelly
- Nobuhiko Oridate (ORCID: https://orcid.org/0000-0002-6968-3028)
- Charles Padua (ORCID: https://orcid.org/0000-0002-2664-7959)
- Danilo Galizia (ORCID: https://orcid.org/0000-0003-4851-5938)
- Grzegorz S. Obara
- Katharine A. Price (ORCID: https://orcid.org/0000-0002-5738-1866)
- Madoka Furukawa (ORCID: https://orcid.org/0000-0001-8816-5325)
- Robert Lewin Metcalf (ORCID: https://orcid.org/0000-0002-8431-1951)
- Thibault Mazard (ORCID: https://orcid.org/0000-0002-5644-9603)
- Sébastien Salas (ORCID: https://orcid.org/0000-0001-6222-5027)
- Helena Rebelo‐de‐Andrade (ORCID: https://orcid.org/0000-0002-0138-0944)
- Aurora Mirabile (ORCID: https://orcid.org/0000-0002-1475-0940)
- Lisa Francesca Licitra (ORCID: https://orcid.org/0000-0003-0623-4118)
- Santiago Cabezas Camarero
- Ann Hoeben (ORCID: https://orcid.org/0000-0003-0155-3005)
- Kenji Okami (ORCID: https://orcid.org/0000-0003-4228-3347)
- Lara Carmen Iglesias Docampo (ORCID: https://orcid.org/0000-0001-6485-4601)
- Paul Swiecicki (ORCID: https://orcid.org/0000-0003-2286-3555)
- Brandon M. Meyers (ORCID: https://orcid.org/0000-0001-9673-6271)
- Yolanda Escobar (ORCID: https://orcid.org/0000-0001-5492-6739)
- Thiago Bueno de Oliveira (ORCID: https://orcid.org/0000-0002-6472-3596)
- Yoshitaka Honma (ORCID: https://orcid.org/0000-0002-4209-4493)
- Danny Rischin (ORCID: https://orcid.org/0000-0002-3368-0386)
- Simon Laban (ORCID: https://orcid.org/0000-0001-6732-7137)
- P. Troyanova
- Sylvie Zanetta (ORCID: https://orcid.org/0000-0003-2002-0255)
- Amanda Psyrri (ORCID: https://orcid.org/0000-0002-4321-766X)
- Cheng Tzu Yen
- Douglas R. Adkins (ORCID: https://orcid.org/0000-0003-3207-8227)
- Jan Demol
- Jorge Blando (ORCID: https://orcid.org/0000-0003-3628-6656)
- Masahiro Tabata
- Manoel Jacobsen Teixeira (ORCID: https://orcid.org/0000-0002-7974-6045)
- Harpal Singh (ORCID: https://orcid.org/0000-0002-6367-2491)
- Ulrich Keilholz (ORCID: https://orcid.org/0000-0001-6773-9406)
- Jean‐Pascal Machiels (ORCID: https://orcid.org/0000-0001-6369-9742)
- José Dinis (ORCID: https://orcid.org/0000-0002-2684-8283)
- Michael S. Hwang (ORCID: https://orcid.org/0000-0003-3451-3413)
- Maria Ghi
- Ricklie Julian
- Vyacheslav Chubenko
- Federica Bertolini (ORCID: https://orcid.org/0000-0002-8112-2936)
- Kevin Joseph Harrington (ORCID: https://orcid.org/0000-0002-6014-348X)
- Konstantin Penkov
- Jan Paul de Boer (ORCID: https://orcid.org/0000-0001-6218-6128)
- А. М. Мудунов (ORCID: https://orcid.org/0000-0002-0918-3857)
- Zia Poonja (ORCID: https://orcid.org/0000-0003-2190-778X)
- Michael Boyer (ORCID: https://orcid.org/0000-0002-0452-2987)
- Clémence Toullec (ORCID: https://orcid.org/0000-0003-1733-6945)
- Stéphanie Henry (ORCID: https://orcid.org/0000-0002-4704-4647)
- Ana Joaquim (ORCID: https://orcid.org/0000-0001-7064-9639)
- Dario Ruscica
- Bhumsuk Keam (ORCID: https://orcid.org/0000-0001-8196-4247)
- Petar Petrov (ORCID: https://orcid.org/0000-0002-3321-6970)
- Robert I. Haddad (ORCID: https://orcid.org/0000-0003-1413-0079)
- Tsutomu Ueda (ORCID: https://orcid.org/0000-0001-9771-3880)
- Milena Perez Mak (ORCID: https://orcid.org/0000-0001-5876-6533)
- Konrad Klinghammer (ORCID: https://orcid.org/0000-0001-6425-4833)
- Martin Smoragiewicz (ORCID: https://orcid.org/0000-0002-4934-6323)
- Michalis V. Karamouzis (ORCID: https://orcid.org/0000-0003-1369-8201)
- Amaury Daste (ORCID: https://orcid.org/0000-0001-5621-812X)
- Robert L. Ferris (ORCID: https://orcid.org/0000-0001-6605-2071)
- Rubi K. Li (ORCID: https://orcid.org/0000-0002-2646-0932)
- Khashayar Esfahani (ORCID: https://orcid.org/0000-0003-2221-3755)
- Marshall R. Posner (ORCID: https://orcid.org/0000-0003-1912-3281)
- Francesco Perri (ORCID: https://orcid.org/0000-0001-8314-8016)
- Ji‐Won Kim (ORCID: https://orcid.org/0000-0001-6426-9074)
- Yi‐Chun Liu (ORCID: https://orcid.org/0000-0002-0988-5226)
- Hee Kyung Kim (ORCID: https://orcid.org/0000-0001-7416-4727)
- P. A. Isaev (ORCID: https://orcid.org/0000-0003-1583-0106)
- Kaoru Tanaka (ORCID: https://orcid.org/0000-0002-4927-1368)
- Paul Clement (ORCID: https://orcid.org/0000-0002-3489-4060)
- П. А. Исаев (ORCID: https://orcid.org/0009-0001-2728-2154)
- Andreas Dietz (ORCID: https://orcid.org/0000-0001-8254-1676)
- Dainik Patel
- Irene García
- Christian Borel
- Ching-Yun Hsieh (ORCID: https://orcid.org/0000-0003-2119-1558)
- Wonyoung Choi
- Carla M. van Herpen
- Roger B. Cohen
- Simon Häfliger
- Olivier Serrano (ORCID: https://orcid.org/0009-0006-4699-9835)
- Prakash Neupane
- Alfonso Berrocal Jaime
- Petr Szturz
- Jin-Ching Lin
- Lorenzo Livi
- Rafaela Pozzobon
- Konstantinos Papazizis
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Cliniques Universitaires Saint-Luc (BE)
- Humanitas University (IT)
- University of California, San Francisco (US)
- China Medical University (TW)
- National and Kapodistrian University of Athens (GR)
- Rega Institute for Medical Research (BE)
- Maastricht University Medical Centre (NL)
- Central Clinical Hospital and Polyclinic (RU)
- Peter MacCallum Cancer Centre (AU)
- Princess Margaret Cancer Centre (CA)
- Seoul National University Hospital (KR)
- Maastricht University (NL)
- Institute of Cancer Research (CA)
- Taichung Veterans General Hospital (TW)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Centre Léon Bérard (FR)
- AstraZeneca (France) (FR)
- IPO Porto (PT)
- Medical Radiological Research Center (RU)
- Dana-Farber Cancer Institute (US)
- Essen University Hospital (DE)
- Abzena (United Kingdom) (GB)
- Royal Marsden Hospital (GB)
- Centre de Recherche en Cancérologie de Lyon (FR)
- China Medical University Hospital (TW)
- AstraZeneca (Japan) (JP)
- The Christie NHS Foundation Trust (GB)
- National Cancer Center Hospital East (JP)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of North Carolina System (US)
- West German Heart and Vascular Center Essen (DE)
- IRCCS Humanitas Research Hospital (IT)
- Comprehensive Clinical Research (US)
- University of Baltimore (US)
- Charité - Universitätsmedizin Berlin (DE)
- University of Pennsylvania (US)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0073
- Citations
- 11
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 11.50
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- F. Hoffmann-La Roche
- Regeneron Pharmaceuticals
- Exelixis
- Les Laboratories Pierre Fabre
- Agios Pharmaceuticals
- BeiGene
- Incyte
- Relay Therapeutics
- Seagen
- Rakuten Medical
- Coherus Biosciences
- Eisai
- Astellas Pharma
- Servier
- Ono Pharmaceutical
- Ipsen
- Qbiotics
- LEO Pharma
- Directorate for Biological Sciences
- Genentech
- EMD Serono
- Daiichi Sankyo Europe