Relationship between sRAGE and obesity in individuals with type 1 diabetes during a median follow-up of 6.3 years
sRAGE is inversely associated with both general and central obesity, as represented by BMI and WHtR, independent of kidney disease, suggesting sRAGE is a biomarker of obesity. However, sRAGE is not associated with the changes in BMI and WHtR over a 6.3 year follow-up. Future research with longer follow-up is merited to understand how sRAGE correlates with body fat accumulation.
Authors
- Per‐Henrik Groop (ORCID: https://orcid.org/0000-0003-4055-6954)
- Markku Lehto (ORCID: https://orcid.org/0000-0001-8414-7285)
- Niina Sandholm (ORCID: https://orcid.org/0000-0003-4322-6942)
- Valma Harjutsalo (ORCID: https://orcid.org/0000-0003-3568-9779)
- Krishna Adeshara (ORCID: https://orcid.org/0000-0002-6960-5505)
- Erika B. Parente (ORCID: https://orcid.org/0000-0002-8101-912X)
Institutions
- Boehringer Ingelheim (Germany) (DE)
- University of Helsinki (FI)
- Baker Heart and Diabetes Institute (AU)
- Helsinki University Hospital (FI)
- Institute for Molecular Medicine Finland (FI)
- Folkhälsans Forskningscentrum (FI)
- Monash University (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s00125-025-06440-4
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Wilhelm och Else Stockmanns Stiftelse
- Finska Läkaresällskapet
- Folkhälsanin Tutkimussäätiö
- European Foundation for the Study of Diabetes
- Academy of Finland
- Biomedicum Helsinki-säätiö
- Novo Nordisk
- Samfundet Folkhälsan
- European Association for the Study of Diabetes
- Novo Nordisk Fonden