Nerol enhances lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated MAPK signaling
Collectively, our findings show that nerol exerts a lipogenic effect on human sebocytes in a CB2-dependent manner through the activation of MAPK pathway, suggesting the therapeutic potential of this monoterpene in controlling cutaneous disorders involving sebaceous gland dysfunction and reduced sebum production, such as atopic dermatitis, skin dryness and aging.
Authors
- Christos C. Zouboulis (ORCID: https://orcid.org/0000-0003-1646-2608)
- Chuntao Zhai
- Xiaolei Ding (ORCID: https://orcid.org/0000-0001-9595-8788)
- Zhenlin Hu (ORCID: https://orcid.org/0000-0001-5529-397X)
- Chengliang Li (ORCID: https://orcid.org/0000-0001-6533-7729)
- Yaozhao Li
- Zhiwei Liu (ORCID: https://orcid.org/0009-0002-9353-015X)
- Juan Wang (ORCID: https://orcid.org/0000-0002-5066-0926)
- Yong Wang (ORCID: https://orcid.org/0000-0003-0448-9619)
- Tan Li (ORCID: https://orcid.org/0000-0002-9386-5059)
- Qiang Ju
- Qi Zhao (ORCID: https://orcid.org/0000-0002-4649-9527)
Institutions
- Shanghai University (CN)
- Commercial Aircraft Corporation of China (China) (CN)
- Renji Hospital (CN)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.jphs.2025.04.008
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00