Non-recurrent mutations and copy number changes predominate pituitary adenoma genomes
This study highlights a role for individualized genetic events in PA formation and suggests that divergent patterns of genomic instability may facilitate tumorigenesis even within the same lineage. Taken together, we demonstrate how gene panels may illuminate novel biology in endocrine tumors.
Authors
- Ticiana Paes (ORCID: https://orcid.org/0000-0003-3078-5200)
- Victor R. Vaz (ORCID: https://orcid.org/0000-0003-3714-2814)
- Timothy R. Smith (ORCID: https://orcid.org/0000-0003-1976-0766)
- David M. Meredith (ORCID: https://orcid.org/0000-0002-7054-8624)
- Wenya Linda Bi (ORCID: https://orcid.org/0000-0002-4635-0247)
- Beatriz Santana Soares
- Antônio Marcondes Lerário (ORCID: https://orcid.org/0000-0002-8336-6432)
- Ursula B. Kaiser (ORCID: https://orcid.org/0000-0002-8237-0704)
- Dipika R. Mohan (ORCID: https://orcid.org/0000-0002-6334-9416)
- Rona S. Carroll (ORCID: https://orcid.org/0000-0002-6804-7177)
- Jacobo Buelvas Mebarak (ORCID: https://orcid.org/0009-0003-2174-4260)
- Ana Paula Abreu (ORCID: https://orcid.org/0000-0002-5505-0852)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Brigham and Women's Hospital (US)
- Roger Williams Medical Center (US)
- Harvard University (US)
- Providence College (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1093/ejendo/lvaf086
- Citations
- 3
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.88