Study of directional pulsed neutron flux generation for BNCT using a high-intensity lithium beam

This paper introduces a novel neutron production system for Boron Neutron Capture Therapy (BNCT) that employs a lithium beam in inverse kinematics to generate forward-directed neutrons through the <sup>7</sup>Li (p,n)<sup>7</sup>Be reaction. The system utilizes a thin polypropylene target and an optimized beam configuration to achieve high neutron yield and precise directional control. A tape target mechanism is incorporated to effectively manage thermal loads, ensuring stable and reliable operation. The proposed system could offer substantial advantages over conventional neutron sources, including enhanced neutron directionality and a reduced shielding requirement. This approach increases the potential for precise tumor targeting while minimizing exposure to surrounding healthy tissues, paving the way for a more accessible and efficient BNCT treatment option.

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Publication Details

Journal
Applied Radiation and Isotopes
Published
2025-04-29
DOI
https://doi.org/10.1016/j.apradiso.2025.111872
Citations
2
Primary Topic
Boron Compounds in Chemistry
Type
article
Field-Weighted Citation Impact
2.72

Funders

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article

Study of directional pulsed neutron flux generation for BNCT using a high-intensity lithium beam

Toshiro Sakabe, Antonino Cannavò, Takeshi Kanesue, M. Okamura et al.
2 citations
Applied Radiation and Isotopes
Boron Compounds in Chemistry
2.72
article

Study of directional pulsed neutron flux generation for BNCT using a high-intensity lithium beam

Toshiro Sakabe, Antonino Cannavò, Takeshi Kanesue, M. Okamura, Giovanni Ceccio, Kazumasa Takahashi, M. Horana Gamage, Shunsuke Ikeda
article en
2 citations

Abstract

This paper introduces a novel neutron production system for Boron Neutron Capture Therapy (BNCT) that employs a lithium beam in inverse kinematics to generate forward-directed neutrons through the <sup>7</sup>Li (p,n)<sup>7</sup>Be reaction. The system utilizes a thin polypropylene target and an optimized beam configuration to achieve high neutron yield and precise directional control. A tape target mechanism is incorporated to effectively manage thermal loads, ensuring stable and reliable operation. The proposed system could offer substantial advantages over conventional neutron sources, including enhanced neutron directionality and a reduced shielding requirement. This approach increases the potential for precise tumor targeting while minimizing exposure to surrounding healthy tissues, paving the way for a more accessible and efficient BNCT treatment option.

Applied Radiation and IsotopesVol. 223
Nagaoka University (JP), Brookhaven National Laboratory (US), Czech Academy of Sciences, Nuclear Physics Institute (CZ), Nuclear Research Institute Rez (Czechia) (CZ), Columbia University (US), Nagaoka University of Technology (JP), Brookhaven College (US)
U.S. Department of Energy, International Atomic Energy Agency, Office of Science, Brookhaven National Laboratory
Affordable and clean energy
Openalex Percentile: Top 11%
Boron Compounds in Chemistry
2.72
DOIOpen Access PDFOpenAlex
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