Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus
Our findings provide support for the hypothesis that the pathophysiology of iNPH is characterized by a state of neuroinflammation, extracellular matrix remodeling, and neurodegeneration, and CSF shunting can reverse such pathological state. Machine learning using preoperative proteomic profiles satisfactorily predicted the clinical outcome of the shunt procedure in iNPH. Future research targeting specific proteins in iNPH may be warranted to better comprehend the disease mechanism and design patient-tailored treatments.
Authors
- Tiannan Guo (ORCID: https://orcid.org/0000-0003-3869-7651)
- Hongjie Jiang
- Jingquan Lin (ORCID: https://orcid.org/0000-0003-1550-3308)
- Zhoule Zhu (ORCID: https://orcid.org/0000-0002-4554-1201)
- Yuqi Ying (ORCID: https://orcid.org/0009-0004-7912-5881)
- Hemmings Wu (ORCID: https://orcid.org/0000-0001-9665-2617)
- Katrina Bartas (ORCID: https://orcid.org/0000-0002-6808-6977)
- Zhe Zheng (ORCID: https://orcid.org/0000-0003-4866-9398)
- Yan Feng (ORCID: https://orcid.org/0000-0002-6507-9077)
- Yuanjian Fang (ORCID: https://orcid.org/0000-0002-0035-6045)
- Weijun Gao (ORCID: https://orcid.org/0000-0003-0299-3686)
- D. M.O. Cheong
- Ligen Shi (ORCID: https://orcid.org/0000-0001-7441-6074)
- Jianmin Zhang (ORCID: https://orcid.org/0000-0002-3184-1502)
- Junming Zhu (ORCID: https://orcid.org/0000-0002-2781-3306)
- Ping An (ORCID: https://orcid.org/0000-0002-0018-2233)
- Liang Yue (ORCID: https://orcid.org/0000-0002-8901-2707)
- Qinghui Zeng (ORCID: https://orcid.org/0009-0002-5705-9188)
- Kevin Beier (ORCID: https://orcid.org/0000-0002-4772-7827)
Institutions
- University of California, Irvine (US)
- Westlake University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.jare.2025.04.043
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91