Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation
This study demonstrated TSG-6 as a positive regulator of tuft cells differentiation by interacting with Pou2f3, and the effectiveness of exogenous TSG-6 treatment on maintaining intestinal barrier integrity showed a promising potential for its clinical application.
Authors
- Bo Zhu (ORCID: https://orcid.org/0000-0002-5829-9581)
- Yuqi Li (ORCID: https://orcid.org/0000-0003-1501-1549)
- Shaopeng Yang (ORCID: https://orcid.org/0009-0003-0673-3731)
- Jiangping Yu
- Rongwei Ruan (ORCID: https://orcid.org/0009-0000-4690-8581)
- Shi Wang (ORCID: https://orcid.org/0000-0002-9571-9864)
- Xiaolan Zhang (ORCID: https://orcid.org/0000-0002-7047-3634)
- Hanmei Lou (ORCID: https://orcid.org/0000-0002-3234-1673)
Institutions
- Zhejiang Cancer Hospital (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s10020-025-01230-5
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59