Epitranscriptomic Analysis of the Ventral Hippocampus in a Mouse Model of Post-Traumatic Stress Disorder Following Deep Brain Stimulation Treatment of the Basolateral Amygdala
We draw two conclusions from these findings: BLA DBS may alleviate PTSD-like symptoms by reversing FS-induced methylation changes and by altering the methylation levels of crucial genes. These findings indicate that epigenetic m<sup>6</sup>A modifications in the vHPC may play an important role in the amelioration of PTSD using BLA DBS.
Authors
- Yin Yao (ORCID: https://orcid.org/0000-0002-5833-5263)
- Hao Fan (ORCID: https://orcid.org/0000-0002-6947-9609)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- Yan Gao (ORCID: https://orcid.org/0000-0002-6541-8577)
- Yizheng Wang (ORCID: https://orcid.org/0009-0002-0710-4075)
- Mingxi Ma
Institutions
- Dalian Medical University (CN)
- Chinese Institute for Brain Research (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/brainsci15050473
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.73