Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)
LO-NMOSD patients presented more often with myelitis, experienced worse attack outcomes and faster disability accumulation, despite comparable AAR, acute attack treatment and long-term treatment regimens. Accordingly, therapeutic strategies for attack and prophylactic treatment in LO-NMOSD have to be improved.
Authors
- Stefan Gingele (ORCID: https://orcid.org/0000-0002-6055-5695)
- Peter Kern (ORCID: https://orcid.org/0009-0006-9459-9131)
- Ingo Kleiter (ORCID: https://orcid.org/0000-0002-8249-4408)
- Jan‐Patrick Stellmann (ORCID: https://orcid.org/0000-0003-2565-2833)
- Brigitte Wildemann (ORCID: https://orcid.org/0000-0002-5389-3338)
- Makbule Şenel (ORCID: https://orcid.org/0000-0002-2737-7495)
- Luisa Klotz (ORCID: https://orcid.org/0000-0001-5439-9633)
- Carolin Schwake (ORCID: https://orcid.org/0000-0003-3669-7244)
- Julian Reza Kretschmer
- Achim Berthele (ORCID: https://orcid.org/0000-0001-9650-6222)
- Yavor Yalachkov (ORCID: https://orcid.org/0000-0002-0805-771X)
- Tania Kümpfel (ORCID: https://orcid.org/0000-0001-7509-5268)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-1647-6201)
- Matthias Grothe (ORCID: https://orcid.org/0000-0002-7998-5310)
- Daria Tkachenko
- Katrin Giglhuber (ORCID: https://orcid.org/0000-0003-3790-2334)
- Patrick Schindler (ORCID: https://orcid.org/0000-0002-8846-121X)
- Marius Ringelstein (ORCID: https://orcid.org/0000-0003-3618-8407)
- Axel Haarmann (ORCID: https://orcid.org/0000-0002-5597-6225)
- Thivya Pakeerathan
- Orhan Aktaş (ORCID: https://orcid.org/0000-0002-2020-9210)
- Markus Kraemer (ORCID: https://orcid.org/0000-0002-5667-3621)
- Judith Bellmann–Strobl (ORCID: https://orcid.org/0000-0003-2615-1643)
- Joachim Havla (ORCID: https://orcid.org/0000-0002-4386-1340)
- Uwe K. Zettl (ORCID: https://orcid.org/0000-0002-6348-1759)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Felix Luessi (ORCID: https://orcid.org/0000-0003-4334-4199)
- Heike Stephanik
- Corinna Trebst
- Matthias Kaste
- Vivien Häußler (ORCID: https://orcid.org/0000-0002-7787-7391)
- Thorleif Etgen (ORCID: https://orcid.org/0000-0002-7857-6435)
- Jörn Peter Sieb
- Klemens Angstwurm (ORCID: https://orcid.org/0000-0003-3220-8829)
- Clemens Warnke (ORCID: https://orcid.org/0000-0002-3510-9255)
- Florian Then Bergh (ORCID: https://orcid.org/0000-0001-8604-8408)
- Martin W. Hümmert (ORCID: https://orcid.org/0000-0002-5928-2343)
- Sven Jarius (ORCID: https://orcid.org/0000-0003-4849-2545)
- Ann-Sophie Lauenstein
- Markus C. Kowarik (ORCID: https://orcid.org/0000-0003-1389-5539)
- Ulrike Wallwitz
- Antonios Bayas (ORCID: https://orcid.org/0000-0002-7418-9040)
- Christian Geis (ORCID: https://orcid.org/0000-0002-9859-581X)
- Daniel Engels (ORCID: https://orcid.org/0000-0002-9877-6987)
- Patrick Oschmann (ORCID: https://orcid.org/0000-0003-1480-0896)
- Sarah Passoke (ORCID: https://orcid.org/0009-0006-3630-8121)
- Eva Dawin (ORCID: https://orcid.org/0000-0002-4755-1534)
- Ilya Ayzenberg (ORCID: https://orcid.org/0009-0007-9491-2180)
- Veit Rothhammer
- Martin S. Weber (ORCID: https://orcid.org/0000-0001-8409-0389)
- Frank Hoffmann
- Lisa Revie (ORCID: https://orcid.org/0000-0003-4911-6883)
- Annette O. Walter
- Katinka Fischer
- Clarissa Zappe
Institutions
- Goethe University Frankfurt (DE)
- Centre National de la Recherche Scientifique (FR)
- Universität Hamburg (DE)
- University of Augsburg (DE)
- University of Cologne (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Ulm (DE)
- Johannes Gutenberg University Mainz (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University of Münster (DE)
- University of Würzburg (DE)
- Helios Dr. Horst Schmidt Kliniken Wiesbaden (DE)
- Bayreuth Medical Center (DE)
- Medizinische Hochschule Hannover (DE)
- Universität Greifswald (DE)
- Deutsche Klinik für Diagnostik (DE)
- Klinikum Görlitz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Zentrum Überleben (DE)
- Herford Hospital (DE)
- Krankenhaus Nordwest (DE)
- University Hospital Magdeburg (DE)
- St. Josef-Hospital (DE)
- Centre de Résonance Magnétique Biologique et Médicale (FR)
- Hertie Institute for Clinical Brain Research (DE)
- Martha-Maria Hospital (DE)
- University of Applied Sciences Stralsund (DE)
- Alfried Krupp Hospital (DE)
- University Hospital Cologne (DE)
- Asklepios (DE)
- Hôpital de la Timone (FR)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- University of Regensburg (DE)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Friedrich Schiller University Jena (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1575613
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Amgen
- Bristol-Myers Squibb
- Bayer
- GlaxoSmithKline
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Guthy-Jackson Charitable Foundation
- Argenx
- Horizon Therapeutics
- Bayer HealthCare
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Friedrich-Baur-Stiftung
- Gemeinsame Bundesausschuss
- Grifols
- Novartis Pharma
- Chugai Pharmaceutical
- Sanofi Genzyme
- Cilag