Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway
Our findings demonstrate thatTricellulin promotes the metastasis of colorectal cancer by activating the TGF-β/SMAD2/3 signaling pathway, and TGF-β1 can reciprocally regulate the expression of tricellulin.We have revealed a novel mechanism by which tricellulin forms a positive feedback loop to promote the growth and metastasis of CRC. This mechanism provides novel insights into CRC progression and suggests potential therapeutic targets.
Authors
- Ruoxi Cheng (ORCID: https://orcid.org/0009-0009-6445-2560)
- Wenfang Yang (ORCID: https://orcid.org/0009-0008-1649-8794)
- Jiean Huang (ORCID: https://orcid.org/0000-0003-0431-1888)
- Yanlin Tan
- Mengbin Qin (ORCID: https://orcid.org/0000-0001-9927-5482)
- Kai Feng (ORCID: https://orcid.org/0000-0003-3388-6728)
- Jinxiu Zhang (ORCID: https://orcid.org/0000-0003-2528-9907)
- Xiaoping Pan (ORCID: https://orcid.org/0000-0002-9350-9230)
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fonc.2025.1562976
- Citations
- 1
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81