Position paper ANMCO: Cardiomiopatia ipertrofica: dalla diagnosi al trattamento
Hypertrophic cardiomyopathy (HCM) is a non-rare genetic cardiomyopathy, with an estimated prevalence of 1:500, characterized by an increase in the left ventricular wall thickness in absence of increased loading conditions. The hypertrophy is mostly asymmetric and predominantly affects the basal septum and anterior wall. Left ventricular outflow tract obstruction, at rest or after provocative tests, is detected in many patients and represents the primary cause of reduced functional capacity, as well as an independent predictor of sudden cardiac death and advanced heart failure. Until about 1 year ago, symptomatic patients despite maximal therapy with beta-blockers or calcium channel blockers, with or without disopyramide, had only basal septal reduction therapy via myectomy or alcohol septal ablation as additional therapeutic options. Today, a new class of drugs that inhibit cardiac myosin activity is available for patients with obstructive HCM.In light of the new treatment perspectives, the correct clinical-therapeutic classification of affected patients becomes of fundamental importance for the cardiologist. The aim of this position paper is to increase the knowledge of cardiologists in the field of HCM, defining its epidemiological, genetic and pathological characteristics, identifying the diagnostic criteria and instrumental methods capable of stratifying the risk profile, with the aim of an optimal therapy tailored on the single patient.
Authors
- Alessandro Navazio (ORCID: https://orcid.org/0000-0001-8417-7783)
- Massimo Grimaldi (ORCID: https://orcid.org/0000-0002-9347-8884)
- Federica Re (ORCID: https://orcid.org/0000-0002-8992-4327)
- Benedetta Carla De Chiara
- Andrea Montalto (ORCID: https://orcid.org/0000-0003-3802-3147)
- Attilio Iacovoni (ORCID: https://orcid.org/0000-0003-0347-6672)
- Piero Gentile (ORCID: https://orcid.org/0000-0003-3360-3548)
- Maria Rosaria Iascone (ORCID: https://orcid.org/0000-0002-4707-212X)
- Fabrizio Oliva
- Enrica Perugini
- Francesca Girolami (ORCID: https://orcid.org/0000-0001-9143-3597)
- Giancarlo Todiere (ORCID: https://orcid.org/0000-0002-3459-026X)
- Laura Scelsi (ORCID: https://orcid.org/0000-0001-9409-691X)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Vittorio Pascale (ORCID: https://orcid.org/0000-0003-0465-4709)
- Daniele Pasqualucci (ORCID: https://orcid.org/0000-0003-4065-2786)
- C Ciampi (ORCID: https://orcid.org/0000-0002-1285-8464)
- Andrea Matteucci (ORCID: https://orcid.org/0000-0002-8831-6178)
- Claudio Bilato (ORCID: https://orcid.org/0000-0003-3474-0579)
- Carla Lofiego
- Maurizio Pieroni (ORCID: https://orcid.org/0000-0002-6830-4292)
- Michele Massimo Gulizia (ORCID: https://orcid.org/0000-0003-1513-7125)
- Michele Emdin
- Santo Dellegrottaglie (ORCID: https://orcid.org/0000-0001-7153-4040)
- Emanuele Tizzani
- Furio Colivicchi (ORCID: https://orcid.org/0000-0001-7187-2234)
- Domenico Gabrielli (ORCID: https://orcid.org/0000-0003-3392-0527)
- Federico Nardi (ORCID: https://orcid.org/0000-0002-7743-2587)
- Pietro Scicchitano (ORCID: https://orcid.org/0000-0003-0471-0053)
- Leonardo De Luca (ORCID: https://orcid.org/0000-0002-8552-1272)
- Irene Bottillo (ORCID: https://orcid.org/0000-0003-0396-7981)
- Giovanna Geraci (ORCID: https://orcid.org/0000-0003-0092-8717)
- Samuele Pentiricci
- Paola Grammatico (ORCID: https://orcid.org/0000-0002-6864-2574)
- Giovanni Quarta (ORCID: https://orcid.org/0000-0002-9816-5879)
- Cristina Basso (ORCID: https://orcid.org/0000-0002-0195-9753)
- Carmine Riccio (ORCID: https://orcid.org/0000-0003-0160-3674)
- Maria Alfarano (ORCID: https://orcid.org/0000-0002-0390-4262)
- Monica De Gaspari (ORCID: https://orcid.org/0000-0001-9528-4883)
- Eluisa La Franca (ORCID: https://orcid.org/0000-0003-3143-8577)
- Marco Corda (ORCID: https://orcid.org/0000-0003-2365-8596)
- Massimo Milli (ORCID: https://orcid.org/0000-0003-4811-6224)
- Cristina Chimenti
- Massimo Di Marco (ORCID: https://orcid.org/0000-0002-4423-5202)
Institutions
- Marche Polytechnic University (IT)
- Altera (United States) (US)
- Policlinico Umberto I (IT)
- Ospedale Maggiore (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Associazione Nazionale Medici Cardiologi Ospedalieri (IT)
- AULSS 2 Marca Trevigiana (IT)
- Ospedale San Filippo Neri (IT)
- Ospedale Maggiore Carlo Alberto Pizzardi (IT)
- Azienda Sanitaria di Firenze (IT)
- Nuovo Ospedale San Giovanni di Dio (IT)
- Ospedale Garibaldi (IT)
- Ospedale Sant'Anna (IT)
- Ospedale Papa Giovanni XXIII (IT)
- Ospedale di Santo Spirito (IT)
- Meyer Children's Hospital (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Health Care Foundation (CA)
- Presidio Ospedaliero (IT)
- Azienda Ospedaliera S.Maria (IT)
- IRCCS San Camillo Hospital (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Azienda Ospedale - Università Padova (IT)
- Azienda Ospedaliera Pugliese Ciaccio (IT)
- Ospedale Sant'Anna (IT)
- Policlinico San Matteo Fondazione (IT)
- Ospedale degli Infermi (IT)
- Azienda Usl Toscana Centro (IT)
- Fondazione Toscana Gabriele Monasterio (IT)
- Accredited Private Hospital Villa Regina (IT)
- Azienda Ospedaliera G. Brotzu (IT)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
- University of Milano-Bicocca (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Giornale italiano di cardiologia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1714/4488.44889
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00