HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer
Our study demonstrates that HJURP is critical for promoting GC proliferation and chemoresistance through the regulation of the MYC/TOP2A transcriptional network. Targeting HJURP might offer a novel therapeutic avenue for GC, necessitating further exploration of its clinical potential. This work underscores the value of investigating histone chaperones as potential targets in cancer treatment.
Authors
- Zhuo Mao (ORCID: https://orcid.org/0000-0001-9012-9825)
- Peng Ma (ORCID: https://orcid.org/0000-0002-4060-2773)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Junjie Chen (ORCID: https://orcid.org/0000-0002-3258-0236)
- Li Xu (ORCID: https://orcid.org/0000-0002-8939-9278)
- Xiwen Li (ORCID: https://orcid.org/0000-0002-5092-854X)
- Yanlin Ren (ORCID: https://orcid.org/0000-0002-7169-6047)
- Shanmin Gao (ORCID: https://orcid.org/0000-0001-8912-5245)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fmolb.2025.1566293
- Citations
- 3
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02