Breast Cancer Risk Modification in Women with Pathogenic Variants in <i>BRCA1</i> , <i>BRCA2</i> , <i>ATM</i> , <i>CHEK2</i> , and <i>PALB2</i>
There is limited information on whether established risk factors increase breast cancer risk from PVs. In the WHI, PV carriers had no substantial (≥2-fold) increase with most risk factors, except potentially MHT in ATM or CHEK2 carriers. The results may inform counseling and research on MHT.
Authors
- Chunling Hu (ORCID: https://orcid.org/0000-0002-6814-4639)
- Rowan T. Chlebowski (ORCID: https://orcid.org/0000-0002-4212-6184)
- Aladdin H. Shadyab (ORCID: https://orcid.org/0000-0002-9693-0522)
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Eric C. Polley (ORCID: https://orcid.org/0000-0002-5152-8740)
- Ryan Bernhisel (ORCID: https://orcid.org/0000-0001-6437-6929)
- Esther M. John (ORCID: https://orcid.org/0000-0003-3259-8003)
- Elisha Hughes (ORCID: https://orcid.org/0000-0002-3145-3913)
- Peter Kraft (ORCID: https://orcid.org/0000-0002-4472-8103)
- Marcia L. Stefanick (ORCID: https://orcid.org/0000-0002-0284-6996)
- Allison W. Kurian (ORCID: https://orcid.org/0000-0002-6175-9470)
- Siddhartha Yadav (ORCID: https://orcid.org/0000-0003-4630-9903)
- Jennifer Lee Caswell-Jin (ORCID: https://orcid.org/0000-0002-5711-8355)
- Rami Nassir (ORCID: https://orcid.org/0000-0001-9914-7851)
- Eudora Hu
Institutions
- Mayo Clinic (US)
- Chicago Department of Public Health (US)
- Palo Alto University (US)
- The Lundquist Institute (US)
- Umm al-Qura University (SA)
- University of California San Diego (US)
- University of Chicago (US)
- Stanford Health Care (US)
- Mayo Clinic in Arizona (US)
- Los Angeles Biomedical Research Institute (US)
- Human Longevity (United States) (US)
- National Cancer Institute (US)
- Myriad Genetics (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0592
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82