Early-life smoking, cardiovascular disease risk, and the mediating role of DNA methylation biomarkers of aging
Early-life smoking status is associated with significantly increased CVD risk. DNAm PhenoAge partially mediates this relationship, suggesting its potential as a target for prevention. Moreover, these findings highlight the need for early smoking prevention to reduce CVD risk.
Authors
- Zhou Cai (ORCID: https://orcid.org/0000-0003-1533-1032)
- Wei Wang (ORCID: https://orcid.org/0000-0002-0957-5762)
- Rui Zhou (ORCID: https://orcid.org/0000-0003-0446-1720)
- Hongcai Wang (ORCID: https://orcid.org/0000-0002-3343-7853)
- Chang Sheng
- Guo‐Qiang Lin (ORCID: https://orcid.org/0000-0002-8209-5263)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Hunan Agricultural University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12967-025-06492-5
- Citations
- 5
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 17.47
Funders
- National Natural Science Foundation of China