PtWAVE: a high-sensitive deconvolution software of sequencing trace for the detection of large indels in genome editing
PtWAVE demonstrated superior accuracy and sensitivity compared to the existing TIDE analysis tools for DNA samples, including large deletions. PtWAVE can accelerate genome editing applications in organisms and cell types in which large deletions often occur when programmable nucleases are applied.
Authors
- Kazuki Nakamae (ORCID: https://orcid.org/0000-0002-4469-664X)
- Yoshiko Nakagawa (ORCID: https://orcid.org/0000-0003-4807-3797)
- Nagaki Ohnuki
- Hidemasa U. Bono (ORCID: https://orcid.org/0000-0003-4413-0651)
- Keisuke Okuhara (ORCID: https://orcid.org/0009-0007-8074-1122)
- S. Ide
Institutions
- Hiroshima University (JP)
- PhoenixBio (Japan) (JP)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12859-025-06139-8
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- New Energy and Industrial Technology Development Organization
- Japan Science and Technology Agency
- Co-creation place formation support program