Formulation And Evaluation of Propranolol Hydrochloride Buccal Emulgel Using Permeation Enhancer and Naturally Occurring Polymer.

Introduction: Propranolol Hydrochloride is a beta-blocker used to treat various cardiovascular conditions. The goal is to enhance the drug's bioavailability and provide a controlled release system suitable for buccal administration. Objectives: The main objectives are to develop a stable buccal emulgel formulation using PHCL and gellan gum, and to evaluate this formulation Methods: PHCL was formulated into various buccal emulgel using gellan gum and different concentrations of oleic acid. The formulations were assessed for organoleptic properties, drug content, pH, viscosity, spreadability, and extrudability. The in vitro drug release was tested, and the optimized formulation was subjected to ex vivo drug release and stability studies. Results: The study investigates the formulation and evaluation of Propranolol HCL emulgel, focusing on drug release and permeability properties. Various formulations (F1-F6) were prepared and tested for in vitro drug release, ex vivo permeability, and stability. The F5 formulation demonstrated superior drug release and permeability, achieving 91.16% drug permeability at 4 hours, compared to 75.48% for the F1 formulation. In vitro release data were analyzed using different kinetic models, with the F5 formulation showing the highest correlation with the Zero-order model, indicating a consistent drug release rate. Stability tests conducted at 40°C and 75% relative humidity confirmed the physical stability of the emulgel. Conclusion: A buccal emulgel was formulated of PHCL using gellan gum. The optimized F5 formulation showed promising results in terms of drug release and stability, making it a potential candidate for further development and scale-up for buccal delivery of PHCL