Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived Streptomyces sp. HDN150000
Three new structures named naphpyrone I-K (<b>1</b>-<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (<b>3</b>) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC<sub>50</sub> values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria.
Authors
- Qian Che (ORCID: https://orcid.org/0000-0003-0610-1593)
- Tianjiao Zhu (ORCID: https://orcid.org/0000-0003-4185-5593)
- Guojian Zhang (ORCID: https://orcid.org/0000-0002-4976-8083)
- Dehai Li (ORCID: https://orcid.org/0000-0002-7191-2002)
- Falei Zhang (ORCID: https://orcid.org/0000-0002-0208-8232)
- Xingtao Ren (ORCID: https://orcid.org/0000-0002-1577-1348)
- Wenxue Wang (ORCID: https://orcid.org/0000-0002-3469-1765)
- Xiaoting Zhang (ORCID: https://orcid.org/0000-0003-2157-8381)
Institutions
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Marine Drugs
- Published
- 2025-04-27
- DOI
- https://doi.org/10.3390/md23050188
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Shandong Province
- Institute of Microbiology, Chinese Academy of Sciences