The Active Ingredients and Mechanisms of Xuefuzhuyu Pills inTreating Hyperprolactinemia Caused by Antipsychotics based onUHPLCQ-TOF-MS/MS, Network Pharmacology, and Molecular DockingValidation
This research manifests that XFZY, as a traditional Chinese medicine formula, proffers a novel pathway for the treatment of antipsychotic-induced HPRL. We elucidated the specific molecular mechanisms underlying the anti-HPRL effects of XFZY and its active ingredients, laying a foundation for the subsequent clinical applications of this formula.
Authors
- Xiufang Zhu (ORCID: https://orcid.org/0000-0002-6660-2034)
- Chaoyi Li (ORCID: https://orcid.org/0000-0002-2639-0516)
- Linliu Du
- Guanli Su (ORCID: https://orcid.org/0000-0002-6372-4642)
- Shanshan Chen (ORCID: https://orcid.org/0000-0001-9723-2403)
- Jianxin Wang (ORCID: https://orcid.org/0000-0003-1516-0480)
- Mingyue Liu (ORCID: https://orcid.org/0000-0003-4017-5211)
- Zihuan Zhang (ORCID: https://orcid.org/0000-0001-9443-3920)
Institutions
- Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Current Computer - Aided Drug Design
- Published
- 2025-04-25
- DOI
- https://doi.org/10.2174/0115734099366667250410061157
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00