Allergic reaction after iodoform-containing intracanal medication application following an endodontic root canal therapy

Abstract Allergic reactions to dental materials are rare globally but can lead to serious complications, including life-threatening conditions. This report presents a rare case of severe allergic reaction to iodoform following endodontic root canal treatment. A 24-year-old healthy female underwent incomplete root canal therapy for the upper right second premolar, during which calcium hydroxide paste containing iodoform was used as intracanal medication. Shortly thereafter, she developed urticarial skin rash and shortness of breath, prompting multiple visits to the emergency department for treatment. Despite the cessation of antibiotics and treatment with steroids and antihistamines, the symptoms persisted, suggesting an alternative cause. Consultation with an endodontist led to the removal of the intracanal filling material in the dental clinic. The patient’s severe allergic symptoms were successfully resolved after the removal of intracanal medication. Subsequent skin prick testing confirmed an allergic reaction to iodine. This case underscores the importance of recognizing and managing allergic reactions to dental materials and emphasizes the critical role of dental professionals in patient safety and care. Early identification and appropriate management of such reactions are essential to prevent consequential complications.