Serum Pharmacochemical Analysis of Mongolian Medicine Agar-8 for Combined Allergic Rhinitis and Asthma Syndrome

Combined Allergic Rhinitis and Asthma Syndrome (CARAS) refers to a respiratory allergic reaction disease that occurs concurrently in both the upper respiratory tract (allergic rhinitis) and the lower respiratory tract (asthma). Mongolian medicine has shown significant efficacy in treating CARAS, particularly Mongolian Medicine Agar-8, which has garnered widespread attention from patients and medical professionals during CARAS treatment. To date, the material basis of Agar-8 in the treatment of CARAS remains unclear. In this study, a serum drug fingerprint of Agar-8 for CARAS was established. The results identified 67 differential metabolized oxidative products in the blood, with seven small molecules being primarily screened. Among these, apigenin, fumaric acid, L-phenylalanine, and deoxycholic acid are suggested as the potential pharmacodynamic substances of Agar-8 in treating CARAS. Therefore, this study lays the foundation for future CARAS research.